Synthesis, Characterization and Biological evaluation of substituted Pyrazole derivatives
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2013, Vol 2, Issue 2
Abstract
The work presented in this article consists of synthesis, characterization and biological evaluation of substituted pyrazole derivatives. Pyrazole derivatives have been shown to have wide variety of pharmacological activities like antimicrobial, antiviral, antihistaminic, antitumor, antipyretic, anti-inflammatory, antidepressant and anticonvulsant. As combination of biologically active moieties into one molecule and synthesis of totally newer moieties have been the methods of research, we present here synthesis of some novel pyrazole derivatives incorporating various biologically active aryl/aryloxy acid derivatives such as ibuprofen, diclofenac, aceclofenac as well as potent antibacterial quinolones, norfloxacin and ciprofloxacin. All the compounds synthesized were evaluated for their antimicrobial activity
Authors and Affiliations
Siddiqui Shakeel Ahmed
Keywords
Related Articles
- EP ID EP649025
- DOI -
- Views 72
- Downloads 0
Formulation and evaluation of combination porous tablet containing naproxen sodium as immediate release and sumatriptan succinate as sustained release
Migraine is a chronic disorder and characterized by splitting headaches. A combination of sumatriptan succinate and naproxen sodium was found to be effective. Time to reach Cmax and biological half-life of both drugs are...
Hot melt extrusion technique and its pharmaceutical applications: A review
Significance of hot-melt extrusion techniques for pharmaceutical applications is growing rapidly over the last three decades. Industrial malleability has allowed hot-melt extrusion (HME) to gain wide acceptance and has a...
Studies on Anti-HIV activity and Cytotoxicity of Wrightia tomentosa Leaf
Wrightia tomentosa leaf extracts and its isolated compounds (isatin, indirubin and indigotin) have been studied for inhibition of HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected M...
Lead toxicity due to paint and other industrial sources and contradiction in its toxicity studies
Lead is one of the oldest known and most widely studied occupational and environmental toxins. Despite intensive study, there is still vigorous debate about the toxic effects of lead, both from low-level exposure in the...
Validated UV Method Development for the Simultaneous Estimation of Rabeprazole sodium and Cinitapride in Tablets
Current research attempts to develop simple, cost effective, and time saving, validated UV spectrophotometric method for the simultaneous estimation of Rabeprazole (RPZ) and Cinitapride (CTP) in tablet formulations by si...