Studies on Anti-HIV activity and Cytotoxicity of Wrightia tomentosa Leaf
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2012, Vol 1, Issue 1
Abstract
Wrightia tomentosa leaf extracts and its isolated compounds (isatin, indirubin and indigotin) have been studied for inhibition of HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells (C-type Adult T Leukemia cells). All the extracts and isolated compounds exhibited cytotoxicity in MT-4 cells (CC50: 8-117 μg/ml) and Indirubin displayed marked cytostatic properties in MT-4 cells (CC50:8.32±3.83 μg/ ml).
Authors and Affiliations
Periyasamy Selvam
Keywords
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