SPECTROPHOTOMETRIC METHODS FOR QUANTITATIVE ESTIMATION OF SPARFLOXACIN IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 2
Abstract
Two simple and sensitive Spectrophotometric methods [A and B] have been developed for the quantitative estimation ofSparfloxacin in bulk and Pharmaceutical dosage forms. Method-A was based on condensation of Sparfloxacin with pdimethylaminocinnamaldehyde to form Schiff’s base, which was yellow colored chromogen and showed the maximumabsorption at 465.0 nm. The Beer’s Law range, regression equation and % recovery studies were found to be 10-50 g/ml,Y = 0.0193X – 0.0038 and 99.73 respectively. Method-B was based on the oxidation of Sparfloxacin with ferric chloridefollowed by complex formation with 1, 10-phenathroline that was a red colored chromogen which showed the maximumabsorption at 515.0 nm. The Beer’s Law range, regression equation and % recovery studies were found to be 5-25 g/ml,Y = 0.0245X – 0.0124and 99.13 respectively. Both the methods were validated and found to be satisfactory.
Authors and Affiliations
Srikar A, Channabasavaraj K. P. , Dharmamoorty G, Nataraj Valmiki , Venu Babu T
Keywords
Related Articles
- EP ID EP118718
- DOI -
- Views 178
- Downloads 0
Simultaneous estimation of amlodipine besylate and olmesartan medoxomil drug formulations by HPLC and UV-spectrophotometric methods
One UV- derivative spectrophotometric and one reverse phase high performance liquid chromatography methods have been developed for the simultaneous estimation of amlodipine besylate, Olmesartan Medoxomil in tablet dosag...
Formulation and Evaluation of Levofloxacin Using Different Types and Concentrations of Superdisintegrants
Levofloxacin is a fluoroquinolone anti bacterial drug effective in the treatment of bacterial conjunctivitis. Levofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. The objective of th...
Ethno Medicines of Kolli Hills at Namakkal District in Tamilnadu and its significance in Indian Systems of Medicine
Evaluation of Diuretic activity from Tylophora indica leaves extracts
Aqueous and alcoholic extracts of Tylophora indica leaves were tested for diuretic activity in rats. The parameters studied on individual rat were body weight before and after test period, total urine volume,&...
Development and Evaluation of a Directly Compressible Co-processed Multifunction Sustained Release Agent for Gliclazide Sustained Release Tablets
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1: 3 were prepared and evaluated. The DCCSRA exhibited good flow an...