Development and Evaluation of a Directly Compressible Co-processed Multifunction Sustained Release Agent for Gliclazide Sustained Release Tablets
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 7
Abstract
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1: 3 were prepared and evaluated. The DCCSRA exhibited good flow and compressibility. The DCCSRA served as a retardant, binder and lubricant in Gliclazide sustained release tablets. By optimization of DCCSRA quantity in formulation, the drug release pattern of the trial formulation was made similar to the release pattern of the reference product of Gliclazide (GLIZID MR 30).
Authors and Affiliations
J. Ayyappan , P. Umapathi , Darlin Quine
Keywords
Related Articles
- EP ID EP124139
- DOI -
- Views 114
- Downloads 0
Eco-Friendly Meloxicam Replaces Eco-Demaging Diclofenac Sodium in Veterinary Practice in South Asia - A Review
Meloxicam is a non-steroidal anti inflammatory drug (NSAIDs). It has been reported as a safe substitute of diclofenac sodium which has been banned for veterinary use in Pakistan, Nepal and India due to its relay toxicity...
Most commonly plant exposures and intoxications from outdoor toxic plants
Over the past two decades, there has been an increased recognition of the importance of wild plant used as food and as source of micronutrients and plant secondary metabolites. Non-cultivated plants are perceived as im...
Design, Synthesis and Antiinflammatory Activity of Novel gamma Tocopherol Naproxen Ester Prodrug.
Naproxen is widely used for the treatment of arthritic pain. It can induce gastrointestinal (GI) side effects ranging from stomach irritation to ulceration and bleeding. These complications are believed to be deter...
Synthesis and Biological Evaluation Of Some 2-Substituted Derivatives Of Benzimidazoles
A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, a ntihistaminic, a ntimicrobial, anticancer, c ycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibit...
Protective role of tetrahydrocurcumin and chlorogenic acid on glycoprotein<br /> changes in streptozotocin-nicotinamide-induced diabetic rats
The present study was to evaluate the individual and synergistic effect of two-plant derived phenolic compounds, namely tetrahydrocurcumin(THC) and chlorogenic acid (CGA) on glycoprotein levels in plasma, liver and kidne...