Dose dependent alterations in epididymal sperm counts of cisplatin or<br /> carboplatin treated male wistar rats
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
Infertility is a major concern for young men of reproductive age under-going chemotherapy. Unfortunately chemotherapeutic treatment for neoplastic diseases commonly impairs fertility either temporally or permanently.In general, chemotherapeutic agents target rapidly dividing germ cells, and it is therefore results in impairment of spermatogenesis leading to depletion in sperm counts in cancer survivors. Though chemotherapeutic agents can cause gonadal injury, the nature and extent of the damage is drug-specific and dose-related. Hence the present study was designed to examine the dose-dependent alterations in epididymal sperm counts of cisplatin or carboplatin treated male wistar rats.
Authors and Affiliations
Y. V. Kishore Reddy , P. Sreenivasula Reddy , M. R. Shivalingam , CNNS Pravallika Gamini
Keywords
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- EP ID EP118745
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