Dose dependent alterations in epididymal sperm counts of cisplatin or<br /> carboplatin treated male wistar rats
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
Infertility is a major concern for young men of reproductive age under-going chemotherapy. Unfortunately chemotherapeutic treatment for neoplastic diseases commonly impairs fertility either temporally or permanently.In general, chemotherapeutic agents target rapidly dividing germ cells, and it is therefore results in impairment of spermatogenesis leading to depletion in sperm counts in cancer survivors. Though chemotherapeutic agents can cause gonadal injury, the nature and extent of the damage is drug-specific and dose-related. Hence the present study was designed to examine the dose-dependent alterations in epididymal sperm counts of cisplatin or carboplatin treated male wistar rats.
Authors and Affiliations
Y. V. Kishore Reddy , P. Sreenivasula Reddy , M. R. Shivalingam , CNNS Pravallika Gamini
Keywords
Related Articles
- EP ID EP118745
- DOI -
- Views 129
- Downloads 0
MANAGEMENT OF THE PATIENT FROM THE SITE OF ACCIDENT TO THE HOSPITAL/ PRE-HOSPITAL CARE
Pre-hospital care is very important in the emergency medical conditions and it can lead to improved patient outcomes. This pre-hospital care is usually offered to the patient on the site of incident and during transfer t...
Inhibition of N-Acyl Homoserine Lactone Mediated Quorum Sensing in Pseudomonas aeruginosa by Phyllanthus emblica and Quercus infectoria
Quorum sensing (QS) is a process that enables bacteria to communicate using secretd signaling molecules called autoinducer. Pseudomonas aeruginosa an opportunistic pathogen in immune compromised patients is under the re...
Modulatory effect of NONI-Herbal formulation against ethylene glycol induced nephrolithiasis in albino rats.
The effect of NONI-herbal formulation against ethylene glycol induced nephrolithiasis in albino wistar rats is summarized in this study. Lithiasis was induced in rats by administering 0.75% ethylene glycol in&...
Phyto-pharmacological and plant tissue culture overview of Tylophora indica (burm f.) Merill.
Tylophora indica is a climbing perennial plant indigenous to India, where it is grows wild in the southern and eastern region and has long-standing reputation as a remedy for asthma (hence the Tylophora asthmatica). The...
Stability-indicating High Performance Thin Layer Chromatographic Determination of Clozapine in Tablet Dosage Form
A simple, selective, precise and stability-indicating high-performance thin-layer chromatographic method of analysis of Clozapine in pharmaceutical dosage form was developed and validated. The method employed TLC alumini...