SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF TRAZODONE HYDROCHLORIDE IN PRESENCE OF ITS ALKALINE DEGRADATION PRODUCT
Journal Title: Innoriginal: International Journal Of Sciences - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Simple, sensitive, precise and low-cost spectrophotometric methods were developed for the determination of trazodone hydrochloride in the presence of its alkaline degradation product in bulk powder and in a pharmaceutical preparation. The proposed spectrophotometric methods involve, second derivative (2D), ratio derivative (1DD), ratio difference, Mean centering, bivariate and dual wavelength. Results and discussion: The regression plot was found to be linear over the range of 1-30 μg mL-1 Conclusions. These methods were validated and successfully applied for the determination of trazodone hydrochloride Trittico ® tablets. The obtained results were statistically compared with those of the reported method by applying t-test and F-value at 95% confidence level, and no significant difference was observed regarding accuracy and precision.
Authors and Affiliations
AHMED M. ABDEL-RAOOF, FATHY M. SALAMA, KHALID A. M. ATTIA, RAGAB A. M. SAID, AHMED EL-OLEMY
Keywords
Related Articles
- EP ID EP431240
- DOI -
- Views 156
- Downloads 0
MATHEMATICAL SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND PROPRANOLOL HYDROCHLORIDE USING DIFFERENT CHEMOMETRIC TECHNIQUES
Introduction: Simultaneous mathematical determination of rosuvastatin calcium and propranolol hydrochloride was described using different methods. The mathematical determination involves different chemometric models, nam...
STAVUDINE LOADED NONIONIC SURFACTANT VESICLES: OPTIMISATION OF FORMULATION, EFFECT OF PROCESS VARIABLES AND CHARACTERISATION
Objective:The present work deals with the preparation, characterization and optimization of stavudine loaded nonionic surfactant vesicles (niosomes) for improvement in therapeutic index and efficacy of stavudine. Method...
SCOPARIA DULCIS: A REVIEW ON ITS PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE
The aim of the study is to describe importance of Scoparia dulcis and the experimental studies that we have reviewed from different sources. Scoparia dulcis commonly known as ‘sweet broom weed’ is distributed throughout...
A SURVEY ON MORBIDITY AND MANAGEMENT OF DIABETES IN KOTTAYAM DISTRICT AND A REVIEW ON RECENT DEVELOPMENTS IN DIABETES TREATMENT
Diabetes Mellitus is a chronic disorder characterized by hyperglycemia with or without glycosuria, resulting from an absolute or relative deficiency of insulin. Clinically, diabetes is characterized by a wide spectrum of...
OVERVIEW ON ANTI-ACNE ACTIVITY OF METHANOL EXTRACT OF DRIED FRUITS OF EMBELIA RIBES
Objective:The present work was undertaken to validate the folk use of traditional Indian medicinal plant in the treatment of skin disorder by using scientific methods. Method:The anti-acne potential of methanol extract o...