SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF TRAZODONE HYDROCHLORIDE IN PRESENCE OF ITS ALKALINE DEGRADATION PRODUCT
Journal Title: Innoriginal: International Journal Of Sciences - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Simple, sensitive, precise and low-cost spectrophotometric methods were developed for the determination of trazodone hydrochloride in the presence of its alkaline degradation product in bulk powder and in a pharmaceutical preparation. The proposed spectrophotometric methods involve, second derivative (2D), ratio derivative (1DD), ratio difference, Mean centering, bivariate and dual wavelength. Results and discussion: The regression plot was found to be linear over the range of 1-30 μg mL-1 Conclusions. These methods were validated and successfully applied for the determination of trazodone hydrochloride Trittico ® tablets. The obtained results were statistically compared with those of the reported method by applying t-test and F-value at 95% confidence level, and no significant difference was observed regarding accuracy and precision.
Authors and Affiliations
AHMED M. ABDEL-RAOOF, FATHY M. SALAMA, KHALID A. M. ATTIA, RAGAB A. M. SAID, AHMED EL-OLEMY
Keywords
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