Spectrophotometric Methods for the Estimation of Third and Fourth Generation Cephalosporins In Dosage Form
Journal Title: International Journal for Research in Applied Science and Engineering Technology (IJRASET) - Year 2017, Vol 5, Issue 6
Abstract
The proposed spectrophotometric methods are rapid, sensitive and reproducible for the analysis of cefdinir(A), and cefepime(B) in pharmaceutical dosage forms with short analysis time. The authors developed reagent for the estimation of cefdinir and cefepime, third and fourth generation cephalosporins respectively using catechol ( or p amino aceto phenone-AAP ) and sodium meta periodate at a λmax of 460 nm. The Beers law range, molar absorptivity and Sandell sensitivity will be 50-250 µg/mL,4.5X103 and 0.03 for cefdinir respectively. In case of cefepime the Beers law range, molar absorptivity and Sandell sensitivity will be 20-250µg/mL,6.05x103 and 0.02 respectively.
Authors and Affiliations
Gurucharana Das V, Ravichandra Reddy. K, Sujatha B
Keywords
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