Spectrum of histopathological changes in fibroadenoma of breast
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 3
Abstract
Introduction Fibroadenoma commonly known as Breast Mouse is freely mobile benign tumour of the breast It is composed of epithelial and stromal components These components may show varied histomorphological changes The aim of the present study is to explore the histopathological features of the epithelium and stroma within and around breast fibroadenomaMaterials and Methods This is a retrospective and prospective unicentre study on total 317 cases of fibroadenoma over a period of two years Formalin fixed specimens were grossed and stained with routine HE Further detailed histopathological examination was doneResults Simple features were noted in 94 whereas 6 showed complex features On detailed HPE proliferative epithelial changes like mild ductal hyperplasia was seen in 735 of cases followed by moderate ductal hyperplasia seen in 126 Among the fibrocystic epithelial changes apocrine metaplasia cystic changes and calcification were observed in 3591 183 and 5 cases respectively Only 71 cases had adjacent parenchyma revealing insignificant changes Increasing age had statistically significant relationship with complex features This is statistically significant with p value 0 Conclusion Histopathological Examination of fibroadenomas should be done thoroughly to see atypical complex changes or any malignant feature Further follow up should be recommended in cases with proliferative changes for early detection of malignancyKeywords Fibroadenoma Histopathological changes Malignant transformation
Authors and Affiliations
Jehan Nizam Ansari, Archana Chirag Buch, Aditi Pandey, Ruby Rao, Ayesha Siddique
Keywords
Related Articles
- EP ID EP475919
- DOI 10.18231/2394-6792.2018.0083
- Views 39
- Downloads 0
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