Spectrum of papillary lesions of breast with immunohistochemistry and review of literature
Journal Title: Indian Journal of Pathology and Oncology - Year 2017, Vol 4, Issue 1
Abstract
Background: Papillary lesions of breast are very rare. They are classified as benign, borderline and malignant. Benign papillary lesions constitute less than 10% of all benign lesions of the breast and malignant papillary are less than 1% of all malignancies of breast. All papillary lesions appear similar on histopathology but they behave differently. Objective: To differentiate the papillary lesions of breast with help of Immunohistochemisry (IHC) markers like P63, CK5/6, CD10 and SMA. Material and Methods: This is retrospective study over a period of 5 years. We have done all above markers on histopathologically diagnosed cases of papillary lesions of breast. Results: Out of 41, benign papillomas were 23 and invasive papillary carcinomas were 8, 5 cases were atypical papilloma and 5 were intracystic papillary carcinoma. The age group of patients was between 21 to 75 years with median age 40years. Lump in the breast was commonest presenting complaint.P63 was the most sensitive markers with minimum cross reactivity. Conclusion: P63, CK5/6, CD10 and SMA can be used to differentiate between papillary lesions of the breast .P63 is more sensitive among all.
Authors and Affiliations
Rupali Bavikar, Sanjay Deshmukh, Tejal Khande
Keywords
Related Articles
- EP ID EP311349
- DOI 10.18231/2394-6792.2017.0011
- Views 98
- Downloads 0
CD30+ Anaplastic large cell lymphoma with bullous lesions: Good results with steroid + cyclosporine treatment
Anaplastic large cell lymphomas (ALCLs) are type of lymphomas with a strong CD30 positivity. A 38 year old lady presented with tender nodules over forearms and thighs, blisters and ulcerations over forearms, swelling of...
Epidemiology of neoplastic eyelid lesions in tertiary care hospital
Introduction Lesions from cutaneous portion of eyelid account for the considerable number of ocular specimens sent to the histopathology laboratory for evaluation Wide spectrum of lesions ranging from nonneoplastic to ne...
Fine-needle aspiration cytology of granulocytic sarcoma: A cytomorphologic analysis
Introduction Granulocytic sarcoma is a rare extramedullary tumor comprising of immature myeloid cells in an extramedullary site which is commonly found with myeloid leukemia acute or chronic or occasionally with chronic...
An autopsy case report on OEIS Complex
OEIS complex is a rare congenital anomaly characterised by omphalocele, exstrophy of bladder, imperforate anus and spinal defects. It is a defect that affects the midline of the lower inferior body. This condition is mos...
Bilateral mature cystic teratoma of ovary: A rare case presentation
Mature cystic teratomas are ovarian neoplasms derived from two to three germ cell layers ie ectoderm mesoderm and endoderm Ovarian teratomas are usually benign tumours of the reproductive age group They usually have righ...