Spherical Crystallization: A Novel Particle Design Technique
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 4
Abstract
Oral route is the most important route of drug administration. In this route, the solid dosage form specially tablets, are the first choice of patient but due to unfavorable physical and mechanical properties their formulation process becomes problematic. Crystallization is the main process in the pharmaceutical industry for particle formation, Where Spherical crystallization is a novel particle engineering technique developed. Basically, it's single step process used for size enlargement of drug. By which crystallization and agglomeration can be carried out simultaneously in one step and which has been successfully utilized for improvement of flowability, compactability and bioavailability of crystalline drugs. General methods of spherical crystallization are spherical agglomeration, emulsion, solvent diffusion method, ammonia diffusion method, neutralization method. Spherical crystallization is having wide applications in pharmaceuticals like improvement of flowability and compressibility of poorly compressible drugs, masking bitter taste of drugs and improving the solubility and dissolution rate of poorly soluble drug. Characterization of spherical crystals can be carried out using Optical Microscopy, Scanning Electron Microscopy, X-ray Powder Diffraction, Fourier Transform Infrared spectroscopy and Differential Scanning Calorimetry. Keywords: spherical crystallization, compressibility, flowbility, solubility.
Authors and Affiliations
Bhagyashree Patil
Keywords
Related Articles
- EP ID EP418324
- DOI -
- Views 114
- Downloads 0
To Study the Mechanisms of Granule Formation in the Wet Granulation Process
Traditionally wet agglomeration processes have been considered an empirical art, with great difficulties in predicting and explaining observed behavior. Industry has faced a range of problems including poor product quali...
Comparative Study for the Assessment of Compliance in Alcoholics and Non-Alcoholic Patients on Anti-tubercular Therapy – A Prospective Observational Study
Background: Compliance to Anti-tubercular therapy is very important for the treatment and also to prevent the relapse or failure of the treatment. Nevertheless, many people fail to adhere to the therapy and various facto...
Application of omics in personalized oral health care: A paradigm shift
Periodontal disease and Dental caries are the most common oral diseases in adult populations worldwide and is a major public health concern due to its substantial cost to the oral health care system. During recent years...
COMPARATIVE STUDY OF ADVERSE DRUG REACTIONS BETWEEN AMLODIPINE AND LOSARTAN IN OUT-PATIENTS OF PRIMARY HEALTHCARE CENTRE
WHO recommends a sample size of at least 600 encounters for drug utilization studies (WHO how to investigate drug use in health facilities, 1993). Based on above recommendation, we used sample size of 600 patients. Amlod...
Effect of heat sterilization on surface characteristics of two different Niti rotary systems – A SEM study
Rotary nickel-titanium instruments have attained great popularity because of their high flexibility, increased elastic limits and better resistance to bending and torsional failure compared to stainless steel instruments...