Spindle Cell Carcinoma: A Rare Malignant Transformation in Neurofibromatosis (NF1): A Case Study
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Neurofibromatosis (von Recklinghausen disease) is an autosomal dominant disorder that occurs about once in three thousand live births. Patients with NF1 have an increased risk of developing malignant tumors, in particular a tendency for some NFs to undergo malignant transformation to a malignant peripheral nerve sheath tumor (MPNST). The reported incidence of malignant transformation of neurofibromas in this condition ranges between 2.4%' and 16.5%. We report a patient in which this malignant transformation was observed to occur in to spindle cell carcinoma which is very rare and not yet reported. Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma. It is a rare tumor with a reported incidence of 2% to 3% of all cutaneous cancers.
Authors and Affiliations
Dr . Rahul Bhargava
Keywords
Related Articles
- EP ID EP205946
- DOI -
- Views 98
- Downloads 0
Effectiveness of Tamsulosin in Prevention of Postoperative Urinary Retention in Female Patients Undergoing Laparoscopic Cholecystectomy under General Anaesthesia
Postoperative urinary retention is one of the most common complications of anesthesia and surgery. It occurs more frequently after lower abdominal and pelvic, gynecologic and anorectal surgeries. Management of Postoperat...
Plasma Vascular Endothelial Growth Factor (VEGF) In Ischemic Stroke – A Comparative Study
Background: Studies done elsewhere in stroke have shown that there is elevated VEGF in patients with ischemic stroke and it can be used as a biomarker in ischemic stroke for early diagnosis and treatment. But human studi...
Pharmacovigilance Study of Antiretroviral Drugs in Tertiary Care Hospital - A Prospective Study
Background: Anti-retroviral therapy present today has reduced morbidity and prolong life span of patients. Globally physicians are faced everyday with problems of adverse drug reactions (ADRs). World health organization...
A Statistical Analysis-AFI with Perinatal Outcome
Objectives: We aimed to evaluate the predictive value of amniotic fluid index (<5) for unfavorable perinatal outcome in phrases of caesarean section for fetal distress, low birth weight, meconium staining, Apgar scores,...
Efficacy of Proprioceptive Neuromuscular Facilitation techniques to Pelvic girdle muscles in improving gait in hemiplegic patients
Objectives: To compare the effects of PNF treatment applied to the pelvic region in patients with hemiplegia acute and chronic stage and investigate whether the duration of hemiplegia affected the results of the treatmen...