Spindle Cell Carcinoma: A Rare Malignant Transformation in Neurofibromatosis (NF1): A Case Study
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Neurofibromatosis (von Recklinghausen disease) is an autosomal dominant disorder that occurs about once in three thousand live births. Patients with NF1 have an increased risk of developing malignant tumors, in particular a tendency for some NFs to undergo malignant transformation to a malignant peripheral nerve sheath tumor (MPNST). The reported incidence of malignant transformation of neurofibromas in this condition ranges between 2.4%' and 16.5%. We report a patient in which this malignant transformation was observed to occur in to spindle cell carcinoma which is very rare and not yet reported. Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma. It is a rare tumor with a reported incidence of 2% to 3% of all cutaneous cancers.
Authors and Affiliations
Dr . Rahul Bhargava
Keywords
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