Spoligotype-defined population structure of drug-resistant Mycobacterium tuberculosis isolates in Eastern Poland
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 4
Abstract
Introduction. The most detrimental impact on the epidemiology of tuberculosis (TB) in Poland may have the spread of tubercle bacilli from outside the country. This is because Poland is geographically situated in close proximity to the former Soviet Union countries, such as Latvia, Estonia, Ukraine, and Russia, where the incidence of TB, including drug-resistant (DR) TB is exceptionally high.Aim. To describe the genetic diversity of DR Mycobacterium tuberculosis isolates, circulating in four provinces (Lublin, Podkarpacie, Podlasie, and Warmia-Masuria) constituting the so-called „Eastern Wall” of Poland.Material and methods. A total of 44 DR M. tuberculosis isolates were spoligotyped. The results were compared with the international spoligotype database (SpolDB4). SpolDB4 and the web-based program SpotClust were used to classify isolates into phylogenetic clades.Results. Spoligotyping resulted in 25 distinct patterns, of which five were not recorded in the SpolDB4. Of the remaining 20 types, 16 (80%) had already been reported in Poland. Most of the spoligotypes (56%) identified were found to be present in Poland’s neighbors, such as Germany, the Czech Republic, Latvia, and Russia. At the phylogenetic level, the T and Haarlem families accommodated 80% of the isolates.Conclusions. The M. tuberculosis population in Eastern Poland displayed features characteristic of a European country. Given the low frequency of imported genotypes and the absence of foreign-born patients, DR-TB in Eastern Poland appears to be due to the local transmission of M. tuberculosis strains that have been active in Poland for many years, rather than to the importation of strains from neighboring countries.
Authors and Affiliations
Tomasz Jagielski, Magdalena Klatt, Zofia Zwolska, Ewa Augustynowicz-Kopeć
Keywords
Related Articles
- EP ID EP55023
- DOI -
- Views 171
- Downloads 0
The emergence of carbohydrate metabolism disorders in the course of pancreatic adenocarcinoma (PC) and chronic pancreatitis (CP) – assessment of insulin level and insulin resistance
Introduction. The incidence of carbohydrate metabolism disorders is estimated at approximately 10-35% of patients diagnosed with chronic pancreatitis (CP) and approximately 40-80% of patients diagnosed with adenocarcinom...
Nowe horyzonty patogenezy i terapii chorób włosów
W pracy przedstawiono nowe horyzonty patogenezy i terapii chorób włosów. W ostatnich latach równolegle z postępem cywilizacji narasta problem łysienia zarówno w aspekcie częstości występowania, jak i ciągle mało skuteczn...
Acute pancreatitis
Acute pancreatitis (AP), which carries 5% of mortality, is one of the most common acute condition in gastroenterology. Alcohol consumption and biliary stone disease cause the most cases of AP. The risk of the post ERCP p...
Vascular complications after cardiac invasive procedures – diagnosis and management
Arterial puncture is related with the risk of bleeding and site complications. Therefore this procedure should be performed by physicians. Vascular complications present an important problem in contemporary invasive card...
Evaluation of vitamin D status in pregnant women in Warsaw – preliminary report
Introduction. Vitamin D deficiency is fairly common throughout the world, in all agegroups. Whereas, in most countries there is still no accurate data providing de tailed informationon specific populations, especially pr...