Sputum Induction for the Diagnosis of Sputum Negative Pulmonary Tuberculosis: A Comparative, Randomised Study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
With the rapid emergence of drug resistant bacilli, it has become important to get bacteriological confirmation of pulmonary TB in sputum smear negative patients. Sputum induction is simple and non-invasive, and may precludes the need for bronchoscopy. A prospective study was conducted among patients with smear-negative pulmonary TB with an objective to collect adequate sample of sputum with induction of sputum and compare sputum induction between nebulized N-acetyl cysteine (NAC), 0.9% normal saline (NS), and 3% hypertonic saline (HS). The consecutive 150 patients were taken fulfilling eligibility criteria and randomised in three groups and received nebulised 3% hypertonic saline, N-acetyl cysteine and 0.9% normal saline. There were 92(61.3%) male and 58 (38.6%) female in study population. The mean age of study group was 39.7 years (range 18-75). Sputum induction was successful in 125(83.3%) patients. Overall, 24.6% (n=37) patients were found positive on smear examination after sputum induction. Induction with 3% HS (n=50) was successful in 94% (n=47) patients while NAC and 0.9% NS induced sputum in 84% (n=42) and 72% (n=36) patients respectively. The percentage of smear positivity among successfully induced sputum was highest in 3% HS group (n=20/47, 42.5%). In conclusion, all the three agents can be used for sputum induction in sputum smear negative pulmonary TB but efficacy of 3% HS is better than other two agents.
Authors and Affiliations
Dr. Ajay Upadhyay, Dr. Kamendra Singh Pawar
Keywords
Related Articles
- EP ID EP485293
- DOI -
- Views 77
- Downloads 0
Bacteriological Profile of Neonatal Septicemia, Antibiogram and Correlation with CRP in A Tertiary Care Hospital
Abstract: Neonatal septicaemia constitutes a significant cause of neonatal mortality in our country. Blood culture which is considered as gold standard for diagnosis is costly and time consuming. CRP is a rapid tool for...
Correlation of C-F PWV and CIMT with BMI in Young Healthy Adults
Abstract:To find correlation of C-F PWV and CIMT with BMI in young healthy adults. Study comprised of 100 healthy subjects from society nearby Dr S. N. Medical College, Jodhpur. Both C-F PWV and CIMT increased with incre...
Tuberculosis in HIV: Correlation of Tuberculin Test and Radiological Presentation of Tuberculosis with CD4 Count
Fight against human immunodeficiency virus (HIV) is incomplete without addressing the problems associated with difficult diagnosis of tuberculosis in HIV-Tuberculosis co infected patients. Chest X-ray and Tuberculin test...
Study of Coverage and Utilization of Prevention of Parent to Child Transmission Services and HIV Status of Children of Seropositive Mothers—a Study Done At Government General Hospital, Kakinada
Abstract: More than 90% of HIV infections in children under the age of 15 years are due to mother to child transmission.Strategies targeting pregnant women help to reduce HIV in children. Hence the present study is taken...
Diagnosis and management of Acute Lymphoblastic Leukemia in children in India
Abstract:The cure rates of cancers in children have increased during the past few years. Children have better prognosis compared to adult patients particularly in cases of Acute Lymphoblastic Leukemia. To achieve this hi...