Środki kontrastowe do obrazowania magnetyczno-rezonansowego na przykładzie związków kompleksowych żelaza
Journal Title: Wiadomości Chemiczne - Year 2013, Vol 67, Issue 7
Abstract
Nuclear magnetic resonance is already a broadly exploited phenomenon both in chemistry and medicine. Magnetic resonance imaging is a routine technique in medical diagnosis readily applied for soft tissues like brain, cardiovascular system or gastrointestinal tract. Contrast agents stepped into the field and enabled better recognition of a lesion in the early stage of a disease. The authors present an introductory description of a fascinating history, classification of contrast agents followed by the mechanisms of their action. Classes of positive and negative contrast agents are described. Further discussion is focused on the T1 (positive) molecular species. The mechanism was divided into (1) inner sphere, where both direct coordination of water molecule and its presence in second sphere is considered (Fig. 1) [1] and (2) an outer sphere mechanism which is assumed for the water molecules diffusing into the surrounding of the paramagnet [21, 28]. Further, the most important requirements for medical applications are given. Those are: high relaxivity, charge-osmolality, stability, toxicity via potential transmetallation of redox activity [42]. Molecular examples are quoted based on previously investigated iron complexes. Majority of them are iron(III) species [68], however, some iron(II) compounds like activable, self-immolative or ParaCEST systems have recently appeared [86, 89]. Iron compounds as positive contrast agents may soon accompany classic gadolinium complexes.
Authors and Affiliations
Nikodem Kuźnik, Marzena Wyskocka
Keywords
Related Articles
- EP ID EP585333
- DOI -
- Views 161
- Downloads 0
60 lat chemii na Uniwersytecie Wrocławskim
Rok 2014 – rok, w którym obchodzona jest 60. rocznica powstania chemii na Uniwersytecie Wrocławskim. W powojennej Polsce znalazło zatrudnienie wielu profesorów uczelni lwowskich. Dobra materialne zostały tam we Lwowie, n...
Oddziaływanie elektronów z cząsteczkami o biologicznym znaczeniu
Recent years have witnessed an increase of the interest in the studies of the interaction of electrons with biologically relevant molecules. This has been mainly motivated by the seminal work, where it has been demonstra...
Dwie dekady chemo-enzymatycznej reakcji Baeyera-Villigera
The Baeyer–Villiger oxidation of ketones to lactones or esters is a reaction of significant interest in organic chemistry owing to very wide range of possible applications, e.g. in the synthesis of antibiotics, steroids,...
Olejki eteryczne jako substancje aktywne lub konserwanty w kosmetykach
An important trend in current cosmetic industry is increasing demand for new, biologically active compounds and preservatives of natural origin. These products constitute a major ingredients of natural (organic) cosmetic...
Spektrometria mas w badaniach skażeń mikrobiologicznych środowiska. Część 2, Kwasy 3-hydroksytłuszczowe jako biomarkery lipopolisacharydów (endotoksyn) ścian komórkowych bakterii gramujemnych
Microorganisms synthesize several monomeric chemical structures that are not found elsewhere in nature, e.g. muramic acid (an amino sugar) and D-amino acids (D-alanine and D-glutamic acid) are ubiquitous in bacterial pep...