STABILITY-INDICATING POTENTIOMETRIC METHOD FOR THE DETERMINATION OF CYCLOBENZAPRINE HCL USING TWO CARBON PASTE ION-SELECTIVE ELECTRODES
Journal Title: Innoriginal: International Journal Of Sciences - Year 2018, Vol 5, Issue 6
Abstract
Objective: Two sensitive and selective carbon paste electrodes were developed and investigated for determination of cyclobenzaprine hydrochloride. Methods: Sensor I was developed using ammomium renikate as an anion exchanger and dibutyl phthalate as a plasticizer while sensor II was developed using phosphotungestic acid as an anion exchanger and dibutyl phthalate as a plasticizer. Results: The proposed electrodes showed a near-nernsation response in the range from 1.00×10-4-1.00×10-2 M and 5.00×10-5-1.00×10-2 M for sensor I and sensor II, respectively. The selectivity of the proposed electrodes to a number of interferences was investigated. Conclusion: Cyclobenzaprine hydrochloride was successfully determined in pure form, pharmaceutical formulation and in the presence of anthraquinone (its oxidative degradation product) using the two proposed sensors.
Authors and Affiliations
Nesrin K Ramadan, Taghreed A Mohamed, Rowayda M Fouad, Azza A Moustafa
APPLICATION OF TLC DENSITOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF ASPIRIN AND OMEPRAZOLE IN PHARMACEUTICAL PREPARATION
Objective: Thin layer denistometric method has been developed for simultaneous determination of aspirin and omeprazole in their new pharmaceutical dosage form. Methods: The densitometric separation process was performed...
RESPONSE OF KHARIF GROUNDNUT (ARACHIS HYPOGAEA) TO LAND LAYOUTS, MULCHES AND NUTRIENT MANAGEMENT
A field experiment was conducted during rainy (kharif) seasons of 2010 and 2011 to study the effect of land configurations, mulches and nutrient management on growth and yield of groundnut (Arachis hypogaea L.) at Junaga...
EFFECT OF FK 506 ON SELECTED ENZYMATIC ACTIVITY LEVELS INVOLVED IN PROTEIN METABOLISM IN ALBINO RAT TISSUES
Background: The plant Gmelina arborea has been traditionally used in India for several medicinal purposes like anthelmintic, diuretic, anti-inflammatory, antibacterial and antidiabetic. Aims: The aim of the present study...
A REVIEW ON LIQUISOLID TECHNOLOGY
This review discusses, out of several techniques available, liquisolid system to improve dissolution rate of water insoluble drugs and to enhance dissolution rate of water soluble drugs. The limited solubility of drugs i...
A REVIEW ON BUCCAL PATCHES
The aim of this article is to study the buccal patches. Buccal patch is a nondissolving thin matrix modified release dosage form composed of one or more polymer films or layers containing the drug and/or other excipients...