Standardization of clinical test data and common reference intervals
Journal Title: Journal of Analytical Bio-Science - Year 2011, Vol 34, Issue 3
Abstract
Currently, there is some between-laboratory variability in the clinical chemistry field. However, some items exhibit differences because of reagents, methods, and analyzers. I analyzed between-laboratory variability using the external quality assessment surveillance conducted by the Japanese Association of Medical Technologists. Serum albumin and calcium showed difference because of reagents. To preserve general clinical values, we have to monitor and maintain our laboratory's accuracy. In addition, we must use only standardized reagents and methods.
Authors and Affiliations
Gen Okada
High sensitive determination of oxysterols in human plasma using gas chromatography-mass spectrometry (GC-MS)
Oxysterols, cholesterol oxidation products, have been important markers for various diseases. For example, it is suggested that 24S-hydroxycholesterol, 27-hydroxycholesterol and 7-ketocholesterol can be used as a marker...
Pathologic background to Apo E- and TG-rich lipoproteins revealed by discrimination via linear regression
Aiming to characterise atherosclerotic risk in individuals with Apo E- and TG-rich lipoproteins, the authors analysed the combined clinical data for Apo E and TG using discrimination via linear regression. The result of...
Evaluation of new Smart Strip instrument for determination of hemoglobin
Before a blood donation for a suitable donor, items are checked as pleasant, safe, and convenient as possible. Among these items are blood specific gravity (SG) or whole blood hemoglobin concentration (Hb conc.). Though...
Influence of NaCl on a protein error in the presence of detergent
Influence of NaCl on the color development of protein error in the presence of detergent was investigated using three dyes (BPB, BCG and BCP) and detergents (Brij 35, Triton X-100 and Tween 20). The influence of NaCl on...
Whole blood concentration of thiamine diphosphate requires correction for red blood cell count in the nutritional assessment of thiamine status
This study examined whether the whole blood (WB) concentration of thiamine diphosphate (TDP) needed to be corrected for hemoglobin concentration (Hb) or red blood cell (RBC) count. TDP levels in whole blood (WB TDP) and...