State of Hypophysis-Gonade System in Women with Polycystic Ovary Syndrome during high Level of Exposure with Manganese and Nickel
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 80, Issue 4
Abstract
Introduction. The authors in previous studies have found a high level of exposure to manganese and nickel in women with polycystic ovary (PCOS). Goal of research. The purpose of conducted research was to assess the pituitary-gonadal system in women with polycystic ovary during high level of exposure with manganese and nickel. Material and methods. Studies were conducted for two groups of women. The first group — control consisted of healthy women of reproductive age. The second group consisted of women with PCOS. From study were excluded women with thyroid disease, diabetes, prolactinomas and other endocrine diseases. Using ELISA, in the early follicular phase measured in serum luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol. All studies were performed with the consent of the patient and with compliance with ethical standards. Statistical processing was carried out with the definition of arithmetic mean, median. The validity of the obtained results was evaluated using following indicators: Shapiro-Wilka test, Fisher's F-test, Mann-Whitney’s U-test. Results. Studies have shown that in women with PCOS there is an increase in LH (p=0,0073). FSH and estradiol are not statistically different from the control group. Only in 23,33 % of cases the ratio of LH/FSH breached the ratio of 2:1. In women with PCOS, a large range of deviation of LH, FSH, and estradiol values from median values was recorded. Such changes can indicate pituitary-gonad system dysfunction. Possible mechanisms of negative effects of manganese and nickel on the pituitary gonad system are still under discussion. Conclusion. The obtained results indicate dysfunction of the pituitary gonad system during high level of exposure with manganese and Nickel. In women with PCOS there are signs of dysfunction of the secretion of gonadotropins and estradiol. The use of LH/FSH for PCOS diagnostics is inappropriate.
Authors and Affiliations
S. V. Gunkov
Keywords
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