Determination of sodium in the liver and changes of the biochemical indicators of the ratches blood syrups for the introduction of Fe2O3 koloid solutions with different nanoparticle sizes
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 79, Issue 3
Abstract
Introduction. The use of nanomaterials, especially nanoparticles, is one of the most promising directions in the development of science and technology of the twentieth century. An important place among them belongs to the iron oxide nanoparticles. Using them in medicine and pharmacy, the limited amount of data that assess the impact on the human body requires careful medical and biological research. The Aim of the Study. The aim was to determine the iron content in the liver and the biochemical parameters of blood in rats, which characterize its functional state after the introduction of colloidal solutions of Fe2O3 with particles of different sizes. Materials and methods of research. In an experiment on male Wistar male rats, the effect of Fe2O3 solutions with particles 19, 75 and 400 nm was investigated. Chemically-analytical, biochemical researches are carried out. Results. The article presents data on the study of a violation of the functional activity of the liver as a result of the accumulation of iron after prolonged flow into the body of rats colloidal solutions of Fe2O3. The established increase in the activativity of the enzymes AST, ALT, an increase in the factor de Rithis indicate the damaging effect of LF. Fe2O3, especially 19 nm on liver cells, their necrosis. An increase in the content of uric acid may indicate that the mechanism of cytotoxic action of Fe2O3 is oxidative stress with the formation of reactive oxygen compounds. Conclusions. The experiment found that the accumulation of iron in the liver, the hepatotoxic effect of the LF Fe2O3 depends on the size of the particles, the dose and the time of exposure. The established violations of biochemical parameters for the influence of colloidal solutions of Fe2O3 can be used in substantiating preventive measures.
Authors and Affiliations
L. V. Bakalo, N. M. Dmytrukha, I. M. Andrusyshina, I. P. Lubyanova, L. A. Klymenko
Keywords
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