Hepatobiliary System Impairment, Oxidative Stress and Differentiated Use of Antioxidants in Patients suffered from Acute and Chronic Pesticide Intoxications
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 80, Issue 4
Abstract
Objective: to substantiate rational criteria of diagnostics and methods of differentiated therapy based on the study of the structure and features of the course of clinical syndromes of hepatobiliary system impairment and oxidative stress in acute and chronic pesticide intoxications. Material and methods. Frequency and features of hepatobiliary system impairment in 308 agricultural workers with pesticide intoxications in the acute and long-term periods were performed. Among them, there were 238 patients with acute poisoning: 162 — with herbicides based on 2,4-dichlorophenoxyacetic acid (2,4-D), 62 — with organophosphorus compounds (OPC), 14 — with synthetic pyrethroids (SP) and 70 — with chronic pesticide intoxication (CPI). Clinical and instrumental, biochemical and statistical methods of research were used. Results and conclusions. Along with neurological disorders, the toxic liver damage was observed in 35,8 % of cases of acute poisoning with herbicides based on 2,4-D, in 51,6 % of cases of OPC poisonings, and in most cases of SP poisonings and CPI. Among clinical manifestations of toxic hepatitis, the prevalence of the cytolytic syndrome and hepatosteatosis, less often in combination with the cholestatic or hepatodepressive syndrome, was observed. The differentiated use of antioxidants — α-lipoic and ursodeoxycholic acid — in the complex treatment of pesticide intoxications was substantiated.
Authors and Affiliations
N. M. Bubalo, G. M. Balan
Keywords
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