State of Indicators of Apoptosis and Angiogenesis Processes in Patients with Inactive Pituitary Adenomas
Journal Title: Міжнародний ендокринологічний журнал - Year 2015, Vol 6, Issue 70
Abstract
In the article, the authors analyze data from 71 patients with inactive pituitary adenomas (IPA) aged 18 to 70 years. The absence of correlation between the decline in eNOS enzyme activity and parameters of pro- and antiapoptosis and angiogenesis regulation was found, indicating the independence of these processes in the mechanisms of IPA formation. In patients with IPA and without burdened family history, the index of eNOS and VEGFR-2 correlation increases that indicates an enhancement in the processes of inhibition of angiogenesis and proliferative activity of tissues. The studies did not establish the dependence of violations in patients with microadenomas and macroadenomas, differences by gender, duration of disease, hereditary genetic traits, etc. This underlines the need for further researches in this direction.
Authors and Affiliations
D. Sh. Kholova, Z. Yu. Khalimova, Yu. M. Urmanova, D. A. Aliieva, H. O. Alimukhamedova
Keywords
Related Articles
- EP ID EP219428
- DOI -
- Views 71
- Downloads 0
Effective variant of type 2 diabetes mellitus treatment
Background. The purpose was to evaluate the efficiency of phytoextract Ferment S6 as a part of comprehensive therapy in patients with type 2 diabetes mellitus (DM). Materials and methods. Thirty patients with type 2 DM...
Combined Atherosclerotic Lesions in Patients with Type 2 Diabetes Mellitus
Introduction. Significant prevalence of atherosclerosis and its complications in patients with type 2 diabetes mellitus (DM) determines the need for further investigations of existing risk factors. Objective. To determin...
Effect of Pro197Leu Polymorphism of the Gene GPX1 on Carbohydrate Metabolism and Anthropometric Indices of Patients with Arterial Hypertension Against the Background of Abdominal Obesity
The aim of our study was to investigate the dependence of carbohydrate metabolism in patients with arterial hypertension and concomitant abdominal obesity depending on Pro197Leu polymorphism of the GPX1 gene. Pro197Leu p...
Peculiarities of changes in the coagulation and fibrinolytic activity in patients with coronary heart disease and concomitant type 2 diabetes mellitus, depending on the presence of diabetic vascular complications
Background. The purpose of this work was to study endogenous coagulation/fibrinolysis markers in patients with coronary heart disease (CHD) and concomitant type 2 diabetes mellitus (DM) and to compare these indices with...
Diet in Diabetes Mellitus Type 1
.