STATUS OF 25-HYDROXYVITAMIN D LEVELS AND SERUM CONCENTRATION OF PROINFLAMMATORY CYTOKINES (IL-6 AND TNF-Α) IN MIDDLE-AGED TRIBAL SUBJECTS OF TRIPURA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 45
Abstract
BACKGROUND There have been many studies conducted so far on Non-Alcoholic Fatty Liver Disease (NAFLD) with its many aspects including its association with 25-hydroxyvitamin D levels and its rather complex interplay with pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumour Necrosis Factor-Alpha (TNF-α). This study was designed to show the development of NAFLD in the young tribal population of Tripura and the link between 25 (OH) Vitamin D and pro-inflammatory cytokines (IL-6 and TNF-ɑ) and the development of NAFLD, while at the same time throws light on the prevalence of 25 (OH) Vitamin D deficiencies and the levels of pro-inflammatory cytokines in the study group. MATERIALS AND METHODS The study is a case control study with final population of 94 cases between 18 and 40 years of age fulfilling inclusion and exclusion criteria and an equal number of subjects from same tribal community age and sex matched taken as control population. RESULTS There was a significant relationship between level of 25 (OH) Vitamin D and fatty liver (OR: 9.46, 95% CI: 4.82 - 18.59; p < 0.001). The mean serum 25 (OH) Vitamin D level in the cases was significantly higher than the controls (17.21 ng/mL + 6.34 ng/mL vs 26.56 ng/mL + 10.63 ng/mL; p < 0.001). There was a significant difference between the mean serum IL-6 levels of the cases and the controls (2.99 + 1.11 pg/mL vs 2.22 + 1.08 pg/mL; p < 0.001) and mean serum TNF-α levels of the cases and the controls (6.99 + 2.81 pg/mL vs 5.40 + 3.08 pg/mL; p < 0.001). Low serum 25 (OH) D [OR: 0.87 (95% CI: 0.83 - 0.92), p = 0.0001] and high IL-6 [OR: 1.71 (95% CI: 1.23 – 2.38), p = 0.0013] and TNF-α [OR: 1.17 (95% CI: 1.02 - 1.34), p = 0.0232] were independently associated with the risk of NAFLD. CONCLUSION 25 (OH) Vitamin D concentration are lower, while that of IL-6 and TNF-α are higher in subjects with fatty liver in comparison to those without. 25 (OH) Vitamin D deficiency and high levels of serum IL-6 and TNF-α were independently associated with the risk of development of NAFLD.
Authors and Affiliations
Arkadip Choudhury, Avik Chakraborty, Animesh Saha
Keywords
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