Status of Oxidant and Antioxidant in Patients with Gynaecological Malignancy Undergoing Therapy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
The present study was undertaken in patients of gynaecological malignancy including carcinoma cervix, endometrium and ovarian to evaluate the status of oxidative stress and antioxidant defence mechanisms after radiotherapy, surgery and chemotherapy. Circulating plasma lipid peroxides as malondialdehyde [MDA] and activities of the defensive enzymes Superoxide Dismutase [SOD] and Catalase [CAT] were measured. Blood samples were collected before treatment and within 24 hours and six weeks after surgery, chemotherapy and radiotherapy. Newly diagnosed women with gynaecological carcinoma [N=111], 30-65 years of age and age- matched clinically healthy women [N=50] were included in the present study. Circulating plasma lipid peroxides and activities of the defensive enzymes SOD and CAT were evaluated. Result: MDA level was found to be markedly elevated at 24 hours after therapy which decreased significantly [p<0.001] after six weeks of therapy. CAT and SOD activities were significantly lower at 24 hours which significantly increased [P<0.001] after six weeks of chemotherapy, surgery and radiotherapy. Fall in MDA and rise in the activities of antioxidants SOD and CAT after six weeks of chemotherapy indicate long term protective and curative effect of above treatment modalities mediated through antioxidant defence
Authors and Affiliations
Suman Gautam1 ,, Seema Mehrotra, M. L. B Bhatt 3,, komal S Pasi, B Anjum, A. A Mahdi1
Keywords
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- EP ID EP390317
- DOI 10.9790/3008-1204070913
- Views 27
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