Stem Cells in the Context of Cervical Cancer
Journal Title: Journal of Regenerative Medicine & Biology Research - Year 2024, Vol 5, Issue 3
Abstract
Cervical carcinoma exhibits a high mortality among females, particularly in less developed countries. 99.7% of cervical cancer occurs due to an HPV infection. Other factors also contribute to the progression of HPV to cervical cancer including using oral contraceptives long-term, tobacco use, partaking in sexual activity at an early age and having multiple partners, low-socioeconomic status and other sexually transmitted infections. The current standard of care does not provide a cure but rather just prolongs the patient’s survival. Patients that have to undergo surgery are burdened by life-long consequences related to the child-bearing ability and the chances of recurrence are not fully eliminated. The theory of cancer stem cells states that most tumor cells die after transient differentiation, but a small number of tumor cells significantly contribute to oncogenesis due to their ability to proliferate and self-renew indefinitely. Developing a treatment that specifically targets these CCSCs could prevent the new tumors from developing since CCSCs may be at the root of metastasis. Recent discoveries in the field of targeted therapy have shown promise including, but not limited to, immune checkpoint inhibitors, anti-angiogenesis agents, poly (ADP-ribose) polymerase (PARP) inhibitors, targeted gene delivery and nanotechnology.
Authors and Affiliations
Hetvi Solanki1, Vincent S Gallicchio1*
Keywords
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- EP ID EP751728
- DOI https://doi.org/10.46889/JRMBR.2024.5303
- Views 3
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