STROMAL CHANGES IN INVASIVE CARCINOMA OF BREAST

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STROMAL CHANGES IN INVASIVE CARCINOMA OF BREAST

Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 10

Abstract

BACKGROUND Breast cancer is the most common malignancy in women worldwide. The current diagnostic and management practices in breast cancer takes into consideration the neoplastic cells only and the tumour stroma is not addressed properly. Recent studies have shown that tumour stroma play an important role in tumourigenesis, its behaviour and response to therapy. In this study, we are trying to describe the histopathological changes in tumour stroma with respect to tumour stroma ratio, microvessel density and tumour associated macrophages. Aims and Objectives- To describe the histopathological changes in invasive carcinoma breast with respect to tumour stroma ratio (TSR), tumour associated macrophages (TAMs) and angiogenesis (Microvessel Density, MVD) Settings- Department of Pathology, Government Medical College, Kottayam. Design- Descriptive study. MATERIALS AND METHODS Study was conducted in first 134 biopsy specimens of invasive carcinoma breast received in the Department of Pathology, during the study period of 16 months (June 2017 to September 2018). Analysis- SPSS software. RESULTS In the present study, 66.4 % cases were of stroma low (stromal density < 50 %) type and 33.6 % cases were of stroma high type (Stromal density ≥ 50 %), comparable with the study conducted by A M Moorman et al. 59 % were found to have low microvessel density (MVD) and 41 % high MVD. Equal proportion of cases were found in TAM low and TAM high group. The association was found to be statistically significant between stromal density and microvessel density (p value 0.042), and also between MVD and TAM (p value of 0.022). CONCLUSION No statistically significant association was detected between age, tumour grade, stage of the tumour, lymph node metastasis, or molecular subtypes with stromal density, microvessel density and tumour associated macrophage density. Statistically significant association was found between microvessel density with stromal density and tumour associated macrophages.

Authors and Affiliations

Chasma K, Sankar S

Keywords

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EP ID EP555240
DOI 10.14260/jemds/2019/151
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