STUDIES ON AN AMIDE BASED MUTUAL PRODRUG: SYNTHESIS AND EVALUATION
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 2
Abstract
The aim of this study has been to prepare a useful drug, which could have broad spectrum of antimicrobial activity including antitubercular action. Thus, an amide-based mutual prodrug (NA-INH) was synthesized by condensing isoniazid with nalidixic acid following single-step synthesis. Its structure was established on the basis of elemental analysis, 1H NMR and Mass spectral data results. The mutual prodrug (NA-INH) was also evaluated for in-vitro antibacterial activity including anti-mycobacterial and antifungal activity.
Authors and Affiliations
Asif Husain*| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110 062, India, Aftab Ahmad| Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia, Shah Alam Khan| Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman
Keywords
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