STUDIES ON AN AMIDE BASED MUTUAL PRODRUG: SYNTHESIS AND EVALUATION
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 2
Abstract
The aim of this study has been to prepare a useful drug, which could have broad spectrum of antimicrobial activity including antitubercular action. Thus, an amide-based mutual prodrug (NA-INH) was synthesized by condensing isoniazid with nalidixic acid following single-step synthesis. Its structure was established on the basis of elemental analysis, 1H NMR and Mass spectral data results. The mutual prodrug (NA-INH) was also evaluated for in-vitro antibacterial activity including anti-mycobacterial and antifungal activity.
Authors and Affiliations
Asif Husain*| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110 062, India, Aftab Ahmad| Health Information Technology Department, Jeddah Community College, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia, Shah Alam Khan| Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman
Keywords
Related Articles
- EP ID EP3550
- DOI -
- Views 333
- Downloads 23
Ataluren: A Novel Targeted Therapeutic Approach for the Treatment of Cystic Fibrosis
A lethal autosomal recessive genetic disease, cystic fibrosis (CF) is most common in Caucasians and the prevalence varies with the ethnic origin of the population. Patients with CF lack adequate levels of the CF transm...
ANTIINFLAMMATORY AND ANTINOCICEPTIVE ACTIVITY OF MORINGA OLEIFERA
The Moringa plant, found in tropical and subtropical countries, provides a rich and rare combination of zeatin, quercetin, kaempferom and many other phytochemicals. It is very important for its medicinal value. Various...
BACTERIOLOGICAL PROFILE OF CHRONIC SUPPURATIVE OTITIS MEDIA IN A TERTIARY CARE CENTRE IN SOUTH INDIA
Background: Chronic suppurative otitis media (CSOM) is a disease of multiple aetiologies and is well known for its persistence despite treatment and may result in permanently disabling and potentially fatal complication...
In Vitro Release Kinetics Study of Indomethacin 12Hr Matrix Tablet From Methocel K4M CR and Methocel K15M CR.
The objective of the present study was to design and evaluate controlled release tablets of Indomethacin, employing release retarding materials semi synthetic polymers Methocel K4M CR and Methocel K15M CR. There were nin...
CHRONOTHERAPY OF NOCTURNAL ASTHMA AND RECENT PATENTS: A REVIEW
The study of biological rhythms is called chronobiology. Many diseases have been found to show rhythm in their symptoms and severity. To treat such diseases the timing of drug administration is matched with circadian rhy...