SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OFAMLODIPINE BESYLATE AND LISINOPRIL DIHYDRATE IN TABLET DOSAGE FORMS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 4
Abstract
Amlodipine Besylate and Lisinopril dihydrate are used for the treatment of hypertension. A binary mixture of Amlodipine Besylate (AML) and Lisinopril dihydrate (LSD) was determined by UV spectroscopic methods. The major aim of this research work is to develop simple, economical, accurate, and precise methods for simultaneous estimation of Amlodipine Besylate (AML) and Lisinopril dihydrate (LSD) in tablet dosage form. The method involved to solve simultaneous equations based on measurement of absorbance at two wavelengths 240nm (λmax of Amlodipine Besylate (AML)) and 218nm (λmax of Lisinopril dihydrate (LSD)). The two drugs followed Beers- Lamberts law over the concentration range of 2μg/ml-30μg/ml for AML and 2μg/ml -30μg/ml for LSD. The accuracy and precision of the methods were determined and the methods validated statically and this technique may be employed to analysed the drug containing Amlodipine besylate (AML) and Lisinopril dihydrate (LSD).
Authors and Affiliations
Manisha Masih*| PhD. Research Scholar, Department of Pharmaceutical Science-Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India., Abhilasha Mittal| Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India., B. C. Nandy| Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India.
Keywords
Related Articles
- EP ID EP3014
- DOI -
- Views 375
- Downloads 18
IMMUNOHISTOCHEMICAL CORRELATION OF E-CADHERIN EXPRESSION WITH DIFFERENTIATION GRADE OF INVASIVE DUCTAL CARCINOMA IN SUDANESE FEMALES
Background: E-cadherin is a cell surface protein involved in cell adhesion, present in normal breast epithelium, and in certain breast carcinoma. The utility of the E-cadherin immunohistochemical stain to distinguish bet...
DESIGN AND DEVELOPMENT OF EUDRAGIT COATED CHITOSAN MICROSPHERES FOR COLON TARGETED DELIVERY
Oral route is the most convenient and preferred route but other routes for CDDS may be used. Rectal administration offers the shortest route for targeting drugs to the colon. However, reaching the proximal part of colo...
PREVALENCE OF HERPES SIMPLEX VIRUS IN CSF SPECIMENS OF NEONATES WITH ENCEPHALITIS BY USING REAL TIME PCR
Background: Herpes simplex virus (HSV) causes a spectrum of clinical manifestations in the central nervous system (CNS). Neonatal HSV infection following exposure to the virus at delivery produces severe disseminated in...
Pharmacognostic Standardization and HPTLC Analysis of the Roots of Aerva ambigua/Aerva leucura
Morphoanatomy of the roots of Aerva leucura plant has been studied with the aim to aid pharmacognostic, phytochemical analysis by using WHO recommended physico-chemical determinations and authentic phytochemical procedur...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF ZALTOPROFEN IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM
A new RP-HPLC method was developed and validated for determination of Zaltoprofen in bulk and tablet dosage form. The estimation was carried out on Enable C18G (250 mm ×4.6 mm, 5 μm) column using Acetonitrile and Water i...