SPECTROPHOTOMETRIC SIMULTANEOUS ESTIMATION OFAMLODIPINE BESYLATE AND LISINOPRIL DIHYDRATE IN TABLET DOSAGE FORMS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 4
Abstract
Amlodipine Besylate and Lisinopril dihydrate are used for the treatment of hypertension. A binary mixture of Amlodipine Besylate (AML) and Lisinopril dihydrate (LSD) was determined by UV spectroscopic methods. The major aim of this research work is to develop simple, economical, accurate, and precise methods for simultaneous estimation of Amlodipine Besylate (AML) and Lisinopril dihydrate (LSD) in tablet dosage form. The method involved to solve simultaneous equations based on measurement of absorbance at two wavelengths 240nm (λmax of Amlodipine Besylate (AML)) and 218nm (λmax of Lisinopril dihydrate (LSD)). The two drugs followed Beers- Lamberts law over the concentration range of 2μg/ml-30μg/ml for AML and 2μg/ml -30μg/ml for LSD. The accuracy and precision of the methods were determined and the methods validated statically and this technique may be employed to analysed the drug containing Amlodipine besylate (AML) and Lisinopril dihydrate (LSD).
Authors and Affiliations
Manisha Masih*| PhD. Research Scholar, Department of Pharmaceutical Science-Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India., Abhilasha Mittal| Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India., B. C. Nandy| Jayoti Vidyapeeth Womens University, Vedant Gyan Valley, Jharna Mahala Jobner Link Road, NH-8, Jaipur Rajasthan-303122, India.
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