STUDIES ON THE ANTI-ALLERGIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE COMPOUNDS ISOLATED FROM ZIZYPHUS MAURITIANA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 3
Abstract
Allergy is a type-I hypersensitivity and occurs when body gives immune response against those antigens which are normally nonpathogenic. It might take a dangerous turn on involvement of complement system. Anaphylactic shock is one of such dreadful reactions. Serious roles are also played by inflammatory enzymes such as Cycloxygenase-1, Cycloxygenase-2 and 5-Lipoxygenase in elevating allergic and inflammatory reactions. Though synthetic anti-allergic and anti-inflammatory drugs are available, but show abnormal effect on other body systems. Natural compounds on the other hand are free from side effects. Zizyphus mauritiana, Lam (Rhamnaceae) is considered to be rich in phytochemicals in Ayurveda. Root barks of Zizyphus mauritiana were dried and powdered under controlled conditions followed by extraction in different solvents with increasing polarity. The ethanolic extract of root barks of Zizyphus mauritiana was found to be rich in many phytochemicals such as alkaloids, emodins, flavonoids, tannins, tritepenoids and saponins. Hence, it was selected to study its anti-allergic and anti-inflammatory potential. Adsorption column chromatography of the ethanolic extract was performed to isolate a fraction called Anti-allergic and Anti-inflammatory Fraction (AAF). In vitro, AAF was found to be effective in inhibiting complement system, COX-1, COX-2 and 5-LOX with IC50 values of 0.052 μg/ml, 0.584 μg/ml, 6.33 μg/ml and 0.99 μg/ml, respectively. From the results it was clear that AAF fraction has good anti-allergic and anti-inflammatory ability
Authors and Affiliations
Suhas Talmale , Arti Bhujade , Mandakini Patil
Keywords
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