IN VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS/FRACTIONS OF IXORA PAVETTA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
Free radicals play an important role in the development of tissue damage and pathological events in living organism. There is a compelling evidence indicates that increased consumption of antioxidants from fruits and vegetables reduces the risk of diseases associated with oxidative stress. In our present study aqueous and ethanolic extract of leaves of Ixora pavetta have been evaluated for in vitro antioxidant activity. Among both extract, ethanolic extract showed potent antioxidant activity. Hence this ethanolic extract was further fractionated using various solvents systems (Pet ether – Chloroform - Ethyl acetate – n Butenol) and evaluated for antioxidant potential. DPPH assay, reducing power assay and H2O2 scavenging assay have been used to evaluate antioxidant potential. Ascorbic acid was used as reference compound for all the assays. All the analysis was made with the use of UV-Visible spectrophotometer. The results of all assays showed that extracts / fractions of Ixora pavetta leaves possess significant free radical scavenging and reducing power properties. n- butenol fraction separated from crude ethanolic extract was found to posses more superior antioxidant potential among all tested fractions in in vitro assays. Hence, it can be concluded that the Ixora pavetta leaves could be pharmacologically exploited for oxidative stress related disorders
Authors and Affiliations
Rupesh S Kanhere , K. Ravindra Reddy , K. N Jayveera3
Keywords
Related Articles
- EP ID EP111958
- DOI -
- Views 158
- Downloads 0
REACTIVE OXYGEN SPECIES AND THEIR ROLE IN PLANT DEFENSE AGAINST PATHOGEN INGRESS
Pathogen infections induce a rapid accumulation of Reactive Oxygen Species (ROS) in plant tissues termed as oxidative burst which is the earliest event in the plant defense response. In non-stressed plant tissues enzymat...
DEVELOPMENT AND INVITRO CHARACTERIZATION OF PACLITAXEL SUSTAINED RELEASE MICROSPHERS
The objective of the present work was to formulate and evaluate sustained release paclitaxel microspheres for treating breast, ovarian and colon cancer effectively. Sustained release paclitaxel microspheres for minimum f...
DIETARY PHYTOCHEMICALS AS PROMISING PREVENTIVE MEASURES FOR SKIN CANCER
Currently, skin cancer occurs at a rate of one in every six Americans (18%), and constitutes more than 30% of all newly diagnosed cancer patients in the world [1, 2]. In skin, UV radiation-induced gene mutations have bee...
HEPATOPROTECTIVE EFFECT OF MALACHRA CAPITATA (L.) AGAINST CARBON TETRA CHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
The present study to investigate the phytoconstituents, acute oral toxicity and hepatoprotective activity of aqueous extract of Malachra capitata (L.) (AMC) using CCl4 induced hepatotoxicity in male Wistar albino rats. T...
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF AMLODIPINE BESYLATE
The aim of present work was to prepare mouth dissolving tablets of Amlodipine besylate, used commonly for the treatment angina pectoris, commonly known as angina, is chest pain due to ischemia of the heart muscle, genera...