IN VITRO ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS/FRACTIONS OF IXORA PAVETTA
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
Free radicals play an important role in the development of tissue damage and pathological events in living organism. There is a compelling evidence indicates that increased consumption of antioxidants from fruits and vegetables reduces the risk of diseases associated with oxidative stress. In our present study aqueous and ethanolic extract of leaves of Ixora pavetta have been evaluated for in vitro antioxidant activity. Among both extract, ethanolic extract showed potent antioxidant activity. Hence this ethanolic extract was further fractionated using various solvents systems (Pet ether – Chloroform - Ethyl acetate – n Butenol) and evaluated for antioxidant potential. DPPH assay, reducing power assay and H2O2 scavenging assay have been used to evaluate antioxidant potential. Ascorbic acid was used as reference compound for all the assays. All the analysis was made with the use of UV-Visible spectrophotometer. The results of all assays showed that extracts / fractions of Ixora pavetta leaves possess significant free radical scavenging and reducing power properties. n- butenol fraction separated from crude ethanolic extract was found to posses more superior antioxidant potential among all tested fractions in in vitro assays. Hence, it can be concluded that the Ixora pavetta leaves could be pharmacologically exploited for oxidative stress related disorders
Authors and Affiliations
Rupesh S Kanhere , K. Ravindra Reddy , K. N Jayveera3
Keywords
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