Study and Evaluation of Extended Spectrum Beta Lactamase in Isolates of Patients Suffering from Urinary Tract Infection in Tertiary Care
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Extended-spectrum β-lactamases (ESBLs) is an enzyme that is produced by bacteria that is able to hydrolyse extended spectrum cephalosporin that causes major therapeutic challenge in the treatment of hospitalized and outdoor patients. Infections because of ESBL producers ranges from uncomplicated urinary tract infection to severe septicemia. TEM type of ESBL is derived from Temoniera, a patient from whom the strain was first isolated in Greece. Beta-lactamases, enzymes has the ability to hydrolyze third-generation cephalosporins and aztreonam and inhibited by clavulanic acid. ESBL-producing bacteria exhibit coresistance to other classes of antibiotics and causing limitation in treatment. Study aimed at early detection of ESBL isolated in urinary tract infection and its prompt treatment. Material and Methods: A prospective study was done in department of microbiology, PMCH, Patna. Urine sample was collected from suspected cases of UTI patients and culture and antibiotic sensitivity was done to find out the ESBL cases. Result: 200 samples of suspected UTI patients from various department of PMCH, Patna was taken. 42 ESBL isolates was detected from total sample. 24.70% cases were ESBL. Conclusion: ESBL detection rate in our hospital was 24.70%. Double disc diffussion method using 3rd generation cephalosporin around the amoxicillin plus clavulanic acid sensitivity disc. Then phenotypic confirmation test was done using Cephalosporin / clavulanate combination discs . Treatment of choice for infections against to ESBL-producing organisms is Carbpenems, but carbapenem-resistant have been reported.
Authors and Affiliations
Smita Kumari, Suresh Narayan Sharma, Shankar Prakash
Keywords
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