Study of ADA Levels in Cerebrospinal Fluid In Relation To Stages of Tuberculous Meningitis And Prognostic Significance of Staging in Tuberculous Meningitis.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Introduction: Tuberculous meningitis is a chronic meningeal infection by Mycobacterium tuberculosis characterized by fever, headache, nausea, vomiting, various levels of conciousness, siezures and raised intra cranial pressure. Materials and methods: The present study "study of ADA levels in cerebrospinal fluid in relation to stages of tuberculous meningitis and prognostic significance of staging in the patients" was carried out in the Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi. • Study Design:- Prospective observational study • Sample Size:- 118 • Study Period:- Sept. 15 to Aug. 16 Results: Increased levels of CSF ADA was found in all cases of tuberculous meningitis(>6mg/dl). Mean level of CSF ADA was higher in MRC stage III (14.97±1.45) than in stage I (9.22±1.45). Mortality was also higher in stage III (20.6%). Conclusion: CSF ADA levels correlate with stage of disease at time of presentation as well as outcome and can be used as a prognostic indicator. Late stage of presentation along with raised CSF ADA levels have bad prognosis and poor chances of survival.
Authors and Affiliations
Dr. Chandra Bhushan Sharma, Dr. Shiny Kumari Khess, Dr. Rishi Tuhin Guria
Keywords
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- EP ID EP597092
- DOI 10.9790/0853-160503120124.
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