Study of Adenosine Deaminase (ADA) Activity in the Serum of Rheumatoid Arthritis Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 2
Abstract
Adenosine deaminase (ADA) is an enzyme involved in purine metabolism. It plays a significant role in the immune system. The aim of this study was to investigate the use of adenosine deaminase levels in rheumatoid arthritis (RA) patients. 50 patients with rheumatoid arthritis and 50 controlled subjects enrolled the study. They were matched in sex and age. ADA estimation was done by using the UV-VIS spectrophotometer in the department of biochemistry SP medical college, Bikaner. The results showed a statistically significant level of serum ADA in RA patients (p<0.0001). From the study it can be concluded that increased serum ADA activities in the patients with RA may be dependent on and reflect the increased phagocytic activity of macrophages and maturation of the T-lymphocytes. Due to the cell-mediated immune response in these patients, the activity of ADA that catalyzes the deamination of adenosine to form inosine is elevated. The results of the study have indicated that serum ADA activity can be useful for diagnosis of RA disease. It can be used for supporting the clinical findings and as an index for disease RA. Keywords: Adenosine deaminase (ADA), purine metabolism, immune system, rheumatoid arthritis (RA), UV-VIS spectrophotometer.
Authors and Affiliations
Shalini V. , Hemlata S. , RK V. , Meenakshy G. , Kim C.
Keywords
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