Study of Adverse Drug Reactions Associated with Antiretroviral Agents At Government General Hospital & GMC, Anantapur
Journal Title: International journal of Emerging Trends in Science and Technology - Year 2015, Vol 2, Issue 6
Abstract
Objectives: To study the adverse drug reactions (ADRs) associated with antiretroviral agents (ARVs) in HIV positive patients. Methods: The present study was a prospective observational study conducted at Government General Hospital, Anantapur from JUNE 2014 – JUNE 2015 (for one year period). Qualified Pharmacologist monitored all the in – patients receiving ARVs during the study period for suspected adverse reactions. WHO causality assessment scale, Modified Hartwig & Seigel scale and Modified Schumock & Thornton scales were applied to assess the causality, severity and preventability of the reported ADRs respectively. All cases and assessments were further reviewed by senior Pharmacologist & Head of the Department of STI. Results: During the study period, 94 ADRs were observed in 71 patients. As per WHO scale, 80 ADRs were probable and 14 were possible. Based on the severity assessment, 10 ADRs were mild, 80 ADRs were moderate and 4 ADRs were severe in nature. Among the reported ADRs, 70 were definitely preventable and 24 were probably preventable. Antiretroviral drugs responsible for ADRs were Zidovudine (46), Stavudine (21), Nevirapine (10), Effavirenz (10), Lamivudine (5), Tenofovir (1), and Retonvir (1),. Among the reported ADRs, major ADRs were Anemia (25), Skin rashes (10), Hepatitis (10), Vomiting (10), Lactic acidosis (9), IRIS (5). Conclusion: Regular monitoring of the HIV patients on ART is essential to identify and resolve ADR related morbidities.
Authors and Affiliations
Dr. K. Santha Bai
Keywords
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