Study of Alteration in Serum Lipids by Enalapril and Ramipril in Albino Rabbits
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 1
Abstract
Hypertension with dislipidemia is becoming a common morbidity, since ACE inhibitors are the first line of antihypertensive drugs so present study was undertaken with the aim to evaluate the possible effects of ACE inhibitor on lipid profile in albino rabbits. Rabbits were divided into 2 groups with 6 in each group. Rabbits of Group I were given Enalapril in dose of 0.50 mg/kg and of group II were given Ramipril in dose of 0.25 mg/kg for a period of 6 weeks. Lipid profile estimation (Serum Total cholesterol, serum HDL, serum LDL, serum Triglycerides and serum VLDL) was done at day 0, 7, 21 and 45 respectively. After analysis Rabbits of group-I (Enalapril) showed 7% decrease in serum cholesterol level at 45th day (P<.05). Serum HDL level increased by 10% and 20% at day 21 & 45 respectively (P<.05). Serum Triglyceride level increases by 8% at day 45 (P<.05). Serum LDL level decreases by 7.8% and 16% at day 21 and 45 respectively.(P<.05 ). There was no significant change in Serum VLDL level. Rabbits of group- II (Ramipril) showed increase in HDL level by 7 % & 12 % at day 21 and 45.(P<.05). Total cholesterol, triglycerides and VLDL levels were not significantaly altered while serum LDL level decreases by 6.8 % at day 45. (P<.05). From our study it was concluded that enalapril had a favourable effect on serum lipid profile by decreasing total cholesterol, increasing serum HDL level. It may increase triglycerides, decrease LDL. Ramipril increase serum HDL and decreases LDL, there is no significant change in cholesterol, TG and VLDL levels.
Authors and Affiliations
Shruti chandra
Keywords
Related Articles
- EP ID EP411138
- DOI -
- Views 109
- Downloads 0
Study on the prevalence of gestational diabetes mellitus at a tertiary care hospital
The prevalence of diabetes is increasing globally. Women with Gestational Diabetes Mellitus are an ideal group for the primary prevention of diabetes as they are at increased risk of future diabetes, predominantly type...
Comparing the adverse drug reactions of conventional versus newer anti epileptic drugs: an observational study
Introduction Neurological disorders have been estimated to account for up to 20% of the nationwide cost of healthcare in developed countries. There is growing concern to assess the Adverse Drug Reactions (ADRs) of anti-...
CNS depressant activity of ethyl acetate leaf extract of Avicennia officinalis in mices
The present study deals with the investigation of the ethyl acetate extracts of Avicennia officinalis leaves was assessed for an effect on the central nervous system (CNS) using neuropharmacological experimental models (...
A review on carbapenem resistance and the role of pharmacist in antibiotic stewardship programmes in India
Carbapenems are a group of β-lactam antimicrobial agents with an exceptionally broad spectrum of activity. They are used as a last resort against many multi drug resistant, gram negative bacteria, and in cases of infecti...
In vitro cytotoxic activity of ethanolic extract of Triumfetta rhomboidea against different cancer cell lines
Triumfetta rhomboidea (TR) is being used in traditional medicine for a variety of ailments. It is widely distributed in tropical and subtropical part of India up to an elevation of 1,200 m in the Himalayas. Triumfetta r...