Study of Antibiogram and Virulence Factors of Moraxella Catarrhalis From a Tertiary Care Hospital
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Background: Moraxella catarrhalis is a known secondary pathogen in COPD. Its antibiogram has not been studied much but is important for empiric chemotherapy. Also, studying its virulence factors is important. Objectives: This study was planned to see antibiogram, virulence factors and biofilm formation. Methods: Over 16 months, M. catarrhalis was isolated from sputum and other samples by inoculating on suitable media and identified using staining and standard biochemicals. Virulence factors studied were lecithinase, lipase and protease, serum resistance assay, and biofilm formation by test tube method. Antibiogram was done by Disk diffusion method using 11 different antibiotics. Results: A total of 60 M. catarrhalis isolates were recovered; 51 from sputum and 9 from other samples. Mean age and male to female ratio of patients with respiratory isolates were 38.4 and 1.8:1 respectively. In 3 cases, M. catarrhalis was found to coexist with M. tuberculosis and S. aureus. All respiratory isolates were susceptible to Ceftazidime and Piperacillin-Tazobactum. Resistance to Prulifloxacin and Cotrimoxazole were considerable, and that against Amoxiclav and Levofloxacin were low. Four isolates were Multi-drug resistant, 3 from sputum and 1 from urine. Lipase was found in 38.4% isolates; lecithinase and protease were absent. Biofilm was shown by 67% isolates. All were serum resistant. Conclusion: M. catarrhalis is a smart pathogen, having array of virulence factors and can cause disseminated infection. Prulifloxacin and Cotrimoxazole are not warranted for empiric therapy, at least in our area.
Authors and Affiliations
Bhattacharyya S, Singh S, Sarfraz A, Jaiswal NK, Kumar R, Sengupta A
Keywords
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- EP ID EP544723
- DOI 10.21276/ijmrp.2017.3.2.047
- Views 67
- Downloads 0
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