Study of Association between PGC-1 Gly482Ser Polymorphism and Hypertension
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2012, Vol 3, Issue 12
Abstract
Blood pressure is one of the main factors in global mortality and was diagnosed according to the WHO criteria. If high blood pressure was not treated, leads to death in most cases. Genetics play a major role blood pressure. For example, 70 percent of high blood pressure in a certain family generally has its roots in genetics rather than environmental issues. Clinical studies have found that insulin resistance and hyperinsulinemia in hypertension are important co-factors. Thus, genetic factors influencing insulin resistance and hyperinsulinemia a genetic basis are for prone to high blood pressure. The gene coding for PGC-1 in tissues with high metabolic activity, such as heart, liver and kidneys are produced and Interaction with estrogen and glucocorticoid receptors or detoxification of reactive oxygen leads to the regulation of blood pressure. PGC-1 contains of several polymorphisms: including IVS42 11T>C, Thr394Thra and Gly482Ser. This study aimed to investigate the frequency PGC-1 Gly482Ser polymorphism in blood pressure in both patients and control group. In this study, Triglycerides, blood sugar and cholesterol and measured their body mass index was calculated. PCR-RFLP for Gly482Ser polymorphism analysis was used. Genotype frequencies of GG, GA and AA, respectively, 32%, 52% and 16% in hypertensive patients, 32%, 48% and 20% in the control group. Allele frequency of G and A, respectively, were 58% and 42% of hypertensive patients and 56% and 44% in the control group. In this study, was not found Difference between the frequencies and this result was that the gene PGC-1 Gly482Ser polymorphism is not associated with blood pressure.
Authors and Affiliations
N. Nikkar*| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran.Nikkarnegin@yahoo.com, F. Sadeghi| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran., M. Farshdoosti-Hagh| Department of Pharmaceutical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Keywords
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