STUDY OF CHANGES IN COAGULATION PROFILE OF PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY USING CARBON DIOXIDE PNEUMOPERITONEUM
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 33
Abstract
BACKGROUND Laparoscopic cholecystectomy is now the gold standard procedure and with over 5,00,000 procedures being done annually, laparoscopic cholecystectomy assumes a great significance in general surgical specialty. This study aims to study the effects of carbon dioxide pneumoperitoneum on the coagulation system of patients undergoing laparoscopic cholecystectomy and make the surgeon aware of the detrimental effects. MATERIALS AND METHODS A prospective clinical observational study of 50 patients selected by systematic sampling method from January 2015 to September 2015 at our institution was conducted to determine the results of changes in coagulation profile of patients undergoing laparoscopic cholecystectomy using carbon dioxide pneumoperitoneum. RESULTS The mean prothrombin time of the patients before surgery is 11.83 seconds. The standard deviation was 1.008 and standard error of mean was 0.143. The mean of prothrombin time 6 hours after surgery was 11.7 seconds. The standard deviation was 0.898 and the standard error of mean being 0.127. The difference in the mean between the two groups was 0.130. The p-value was 0.0109 (<0.05). Hence, the value was statistically extremely significant. The values for D-dimer were analysed. The mean value of D-dimer before surgery is 129.78. The standard deviation was 21.01 and standard error of mean was at 2.97. In the D-dimer values after surgery, mean was calculated to be 350.22 with the standard deviation at 73.21 and standard error of mean at 10.35. CONCLUSION Our study concluded that there is activation of both coagulation and fibrinolytic systems post laparoscopic cholecystectomy.
Authors and Affiliations
Vasuki Rajam, Kalpana Devi Agirimangalam Kathaperumal, Bharath Narayanaswami, Madan Kuppusamy
Keywords
Related Articles
- EP ID EP218716
- DOI 10.18410/jebmh/2017/387
- Views 108
- Downloads 0
PREVALENCE OF HEPATITIS C VIRUS INFECTION IN NON INSULIN DEPENDENT DIABETIC PATIENTS (NIDDM)
The present study was done to evaluate the prevalence of hepatitis C virus (HCV) infection in non-insulin dependent diabetic patients (NIDDM) and to investigate influence of HCV seropositivity on several factors such as...
PREVALENCE OF H. PYLORI IN DUODENAL ULCER PERFORATION
BACKGROUND Duodenal ulcer perforation is among common surgical emergencies. Recent data suggests that more than 99% of all duodenal ulcers having infection with H. pylori is associated with use of NSAIDS. There is a nece...
THE PREVALENCE OF ALCOHOL USE PROBLEMS AMONG AUTORICKSHAW DRIVERS IN RURAL KERALA- FINDINGS FROM A COMMUNITY-BASED PILOT STUDY
BACKGROUND Alcohol Use Disorders (AUD) form a major public health concern especially in a developing country like India. Alcohol is implicated in a wide variety of diseases, disorders and injuries and a multitude of soci...
TYMPANOMETRIC FINDINGS AMONG CHILDREN WITH ADENOID ENLARGEMENT
BACKGROUND Adenoid hypertrophy (AH) is a common disorder of childhood.1 Adenoid or nasopharyngeal tonsil plays a significant role in the pathogenesis of otitis media with effusion (OME). Enlarged adenoids cause obstructi...
EFFICACY OF DIRECTLY ACTING ANTIVIRAL DRUGS FOR HCV IN REAL LIFE: EXPERIENCE FROM A TERTIARY CARE CENTRE OF NORTH INDIA
BACKGROUND Since its discovery, treatment of hepatitis C virus (HCV) has undergone extensive changes. Antiviral treatments and sustained virological responses (SVR) have also improved from the early interferon monotherap...