Study of Clinico Pathological Correlation in Autoimmune Bullous Disorders.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Background: Immune mediated vesiculobullous diseases can be diagnosed by close attention to the clinical details, histological confirmation and the clinical setting of the blistering. Confirmatory studies such as immunofluorescence will help in diagnosis of cases where histopathological features alone are not diagnostic. To evaluate clinical findings in association with histopathological findings, to study the histopathological findings in various immunobullous lesions of skin, and to confirm with immunofluorescence wherever possible Aim: The aim is to study histopathology of various Autoimmune vesicobullous disorders and its correlation with clinical evaluation in patients attending DVL department, Guntur medical college. Material & Methods : A total of 80 patients of various bullous disorders attending to department of DVL in one and half year period from July 2015 to december 2016 were analysed. of these females (44), males (33), and (3) were children .The clinical features and histopathology were correlated for the diagnosis and direct immunofluorescence (DIF) was done whenever necessary. Results: out of 80 patients we studied, females were 44( 55 %), males 33(41.25%), children 3 (3.75%). 40 to 50 yrs age group were more commonly affected .we studied & correlated histopathology and DIF with clinical findings , of these 43 patients (53.7%) were pemphigus vulgaris. 18 (22.6 %) were bullous pemphigoid. 4 were (2.51%) Dermatitis herpetifiormis, 2 (2.51 %) were pemphigus vegetans, 5 were pemphigus foliaceous(6.25%) , 3 were CBDC ( 3.72%) . Discussion & Conclusion : Histopathology findings were correlated with clinical diagnosis in majority (95.5%) of autoimmune bullous disorders except few cases (5.25%) where diagnosis is done by immunoflourescence findings. To conclude, the correlation between clinical findings, Histopathology and Immunofluroscence plays a predominant role to confirm the atypical appearance of autoimmune blistering diseases.
Authors and Affiliations
Nageswaramma . S, D. S. S Srinivas Prasad, P. V. Sivaram Sandeep
Keywords
Related Articles
- EP ID EP598112
- DOI 10.9790/0853-1605102530.
- Views 51
- Downloads 0
Haematological Parameters in Patients with Alcohol Dependence Syndrome
Objective: Alcohol has direct toxic effect on bone marrow and also indirect effect on precursors of all blood cells - red blood cells, platelets and white blood cells. Long term excessive alcohol consumption can interfer...
Clinical Study of Meconium Stained Liquor in Labour Induced with Misoprostol and Its Significance on Fetal Outcome
BACKGROUND &OBJECTIVES: induction of labour constitutes initiating effective uterinecontractions which will help in cervical dilatation and delivery of the baby before onset of spontaneous labour. This study evaluates th...
Effects of Diagnostic Mydriasis on Distant and Near Vision
To determine the effects of diagnostic mydriasis using 1% tropicamide and 2.5% phenylephrine on the distant and near vision of patients attending the Eye Clinic of University of Port Harcourt Teaching Hospital, an interv...
Large Fibroid Complicating Pregnancy
The uterine fibroids are very common in the reproductive age group. During pregnancy, it may undergo rapid growth and red degeneration. It may get infected during puerperium. Most of the fibroids are asymptomatic. Women...
“Markedly Elevated Serum Alkaline Phosphatase in A Pregnancy with Acute on Chronic Chorioamnionitiswith Encephalocele,MeningoceleAnd Hydrocephalus in Fetus.”
In normal pregnancy, although maternal serum alkaline phosphatase increases and reaches the twofold of non-pregnant serum level, above this level, hepatic, renal, bone diseases and malignancies should be kept in mind. We...