Study of coagulation profile in IHD patients
Journal Title: Medpulse International Journal of Physiology - Year 2018, Vol 7, Issue 1
Abstract
Background: Epicardial coronary arteries are the major site of atherosclerotic disease. A thrombus composed of platelet aggregates and fibrin strands traps red blood cells and can reduce coronary blood flow, leading to the clinical manifestations of ischaemic heart disease (IHD). A positive association of coagulation factors has been implicated with risk of IHD. This study was under taken to assess the association of coagulation factors in IHD patients by comparing them to normal subjects. Methods: This case control study includes fifty IHD male patients aged 30-50 years as cases and fifty apparently healthy age and sex matched male subjects as controls. Venous blood samples were collected from the subjects which were analyzed for coagulation parameters such as prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen levels. Result: The PT and aPTT in cases were significantly lower and fibrinogen levels were higher in cases than in controls. Conclusion: Shortened levels of PT and aPTT are seen in IHD patients than compared to normal subjects and hence these tests prove as reliable diagnostic tools for IHD. Higher fibrinogen levels, by means of increasing viscosity, also seems to be n independent risk factor for IHD.
Authors and Affiliations
Aiesha Durrebar Younus Khan, Ashwini D Pujari
Keywords
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