Study of Drug-Drug Interactions: A Potential Need for Safe And Effective Usage Of Drugs In A Teritiary Care Hospital
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
Objectives: The main objectives of the study was to identify and classify the drug-drug interactions based on their severity, Mechanism , Clinical Outcome and to identify the most frequently interacting drug combination for the departments of General Medicine, General Surgery, Gastroenterology, Orthopedics, Gynecology and Dermatology. Methodology: A prospective observational study was conducted for six months. The data of patients was collected and analyzed from inpatient departments of General Medicine, General Surgery, Gastroenterology, Orthopedics, Gynecology and Dermatology respectively. Results: A total of 250cases were observed and 150 cases containing Drug-Drug Interactions are considered for the study during the period of August-2016 to January-2017. Out of which 25 cases from each department were considered, analyzed and interpreted using Micromedex database. The prevalence of Actual DDI’s was greater compared to the potential DDI’s and was highest in the gastroenterology department. The prevalence of Moderate DDI’s was highest compared to the Major DDI’s and the prevalence of pharmacodynamic DDI’s is highest when compared to the pharmacokinetic mechanism. A list of repeating combinations was prepared and it was observed that the combinations differ from department to department. Conclusion: From the study it can be concluded that most of the drug-drug interactions occurring were potential in occurrence, moderate in severity and usually would take place through Pharmacodynamic mechanism.
Authors and Affiliations
Ramya Balaprabha G, Sai Mahitha Ch, Aparna K2 ,, Vikas Patnaik N, Shikha Singh2 ,, Dr. Abbulu K
Keywords
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