Study of Glucose Tolerance Test and Thyroid Profile in Tranfusion Dependent Thalassemic Children and Their Correlation with Serum Ferritin Level.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 5
Abstract
Background: The present study was designed to estimate the serum levels of total T4, total T3, TSH, glucose level and serum ferritin in multi-transfused thalassaemic patients and to see any correlation between thyroid hormone dysfunction, glucose dysfunction and high serum ferritin value. Methods: Hospital based observational study conducted at Department of Pediatrics, S.P. Medical College and P.B.M. Associated Group of Hospitals, Bikaner. Results: The mean age of patients was 9.55±3.76 years. The age ranged from 5 years to 18 years. 41.3% were male in age group 5-10 years, 45% male were in 11-15 years and 47.2% males were in age group 16-18 years. 42.5% Hindu patients, 50.7% patients were Muslims and 6.8% patients includes Sindhi and Jews etc. 78.1% patients belong to urban area and 21.9% patients belong to rural area. 43.8% patients belong to lower class, 31.5% patients belong to lower middle, 13.7% patients belong to middle class, 9.6% patients belong to upper middle and only 1.4% patients belong to upper class. 5.5% patients had splenectomy and rest 94.5% did not had splenectomy. 16.4% patients had Family history of diabetes mellitus and 83.6% had no family history. 35.6% patients had family history of thalassemia and 64.7% had no family history. 45.2% patients had history of consanguinity and these patients were Muslims. 54.8% patients had no family history of consanguinity. 6.8% had serum ferritin level >2000 ng/ml, 17.8% had serum ferritin level between 2000-3000 ng/ml, 19.2% had serum ferritin level between 3000-4000 ng/ml, 12.3% had serum ferritin level between 4000-5000 ng/ml, 13.7% had serum ferritin level between 5000-6000 ng/ml and 30.2 had serum ferritin level >6000ng/ml. <10 centile there were 5 (45.4%) patients having thyroid dysfunction, in 10-50 centile there were 5 (45.4%) patients having thyroid dysfunction, in 50-90 centile there were 1 (9.2%) patients having thyroid dysfunction and in >90 centile there were 0 patients having thyroid dysfunction. In males there were 5 (45.5%) patients having thyroid dysfunction, in females there were 6 (54.5%) patients having thyroid dysfunction. In patients having monthly transfusion there were 4 (36.4%) patients having thyroid dysfunction, having bi-monthly transfusion there were 5(45.4%) patients having thyroid dysfunction and having tri-monthly transfusion there were 2 (18.2%) patients having thyroid dysfunction. 10 patients having thyroid dysfunction Thalassemia were diagnosed at below 1 year, 1 patients having thyroid dysfunction Thalassemia were diagnosed at age between 1-5 year. 2 (18.2%) patients having thyroid dysfunction blood transfusion occur from last 5 year and from 5-10 years each, 7 (63.8%) patients having thyroid dysfunction blood transfusion occur from more than 10 years. Conclusion- High prevalence of HT among thalassemic patients signifies the importance of regular screening for evaluation of endocrine function in these patients.
Authors and Affiliations
Renu Agrawal
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