Study of Glucose Tolerance Test and Thyroid Profile in Tranfusion Dependent Thalassemic Children and Their Correlation with Serum Ferritin Level.

Abstract

Background: The present study was designed to estimate the serum levels of total T4, total T3, TSH, glucose level and serum ferritin in multi-transfused thalassaemic patients and to see any correlation between thyroid hormone dysfunction, glucose dysfunction and high serum ferritin value. Methods: Hospital based observational study conducted at Department of Pediatrics, S.P. Medical College and P.B.M. Associated Group of Hospitals, Bikaner. Results: The mean age of patients was 9.55±3.76 years. The age ranged from 5 years to 18 years. 41.3% were male in age group 5-10 years, 45% male were in 11-15 years and 47.2% males were in age group 16-18 years. 42.5% Hindu patients, 50.7% patients were Muslims and 6.8% patients includes Sindhi and Jews etc. 78.1% patients belong to urban area and 21.9% patients belong to rural area. 43.8% patients belong to lower class, 31.5% patients belong to lower middle, 13.7% patients belong to middle class, 9.6% patients belong to upper middle and only 1.4% patients belong to upper class. 5.5% patients had splenectomy and rest 94.5% did not had splenectomy. 16.4% patients had Family history of diabetes mellitus and 83.6% had no family history. 35.6% patients had family history of thalassemia and 64.7% had no family history. 45.2% patients had history of consanguinity and these patients were Muslims. 54.8% patients had no family history of consanguinity. 6.8% had serum ferritin level >2000 ng/ml, 17.8% had serum ferritin level between 2000-3000 ng/ml, 19.2% had serum ferritin level between 3000-4000 ng/ml, 12.3% had serum ferritin level between 4000-5000 ng/ml, 13.7% had serum ferritin level between 5000-6000 ng/ml and 30.2 had serum ferritin level >6000ng/ml. <10 centile there were 5 (45.4%) patients having thyroid dysfunction, in 10-50 centile there were 5 (45.4%) patients having thyroid dysfunction, in 50-90 centile there were 1 (9.2%) patients having thyroid dysfunction and in >90 centile there were 0 patients having thyroid dysfunction. In males there were 5 (45.5%) patients having thyroid dysfunction, in females there were 6 (54.5%) patients having thyroid dysfunction. In patients having monthly transfusion there were 4 (36.4%) patients having thyroid dysfunction, having bi-monthly transfusion there were 5(45.4%) patients having thyroid dysfunction and having tri-monthly transfusion there were 2 (18.2%) patients having thyroid dysfunction. 10 patients having thyroid dysfunction Thalassemia were diagnosed at below 1 year, 1 patients having thyroid dysfunction Thalassemia were diagnosed at age between 1-5 year. 2 (18.2%) patients having thyroid dysfunction blood transfusion occur from last 5 year and from 5-10 years each, 7 (63.8%) patients having thyroid dysfunction blood transfusion occur from more than 10 years. Conclusion- High prevalence of HT among thalassemic patients signifies the importance of regular screening for evaluation of endocrine function in these patients.

Authors and Affiliations

Renu Agrawal

Keywords

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  • EP ID EP574397
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How To Cite

Renu Agrawal (2019). Study of Glucose Tolerance Test and Thyroid Profile in Tranfusion Dependent Thalassemic Children and Their Correlation with Serum Ferritin Level.. International Journal of Medical Science and Innovative Research (IJMSIR), 4(5), 28-32. https://europub.co.uk/articles/-A-574397