Study of Histopathological Changes in Kidney of Male Wistar Rats after Contrast Induction
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 9
Abstract
Use of iodinated contrasts in day to day clinical practice is increased in diagnosis and treatment. Its impact on the kidney has not studied extensively. As per the previous literature reviews, use of iodinated contrast has a impact on kidney leading to AKI (acute Kidney Injury). Current research is under take to fill the lacunae of histopathological changes after inducing the contrast. 36 male wister rats used in the study to evaluate the impact of contrast on histopathological changes. Animals were grouped in to 6 groups including control group. Animals were euthanized at 3 hours, 6 hours, 12 hours, 24 hours, 48 hours of contrast induction and kidney were dissected out for histopathological studies. The light microscopic finding in the kidney of male wistar rats has shown normal appearance of the kidney in control animals. But contrast exposed kidneys of group 1 (3 hours), group 2 (6 hours) and group 3 (12 hours) has showed remarkable changes such as decreased bowmen’s capsular space, infiltration of lymphocytes, mild to moderate inflammation with infiltration of inflammatory cells particularly lymphocytes noticed in renal pelvis region of the kidney, mild epithelial cell hyperplasia noticed in renal pelvis region. Tissue necrosis and acute tubular necrosis was also observed. The present histopathological study confirmed significant changes in tubular vacuolar transformation, interstitial edema and tubular degeneration, infiltration of lymphocytes, hyperplasia at real pelvis region when Contrast media (CM) are used frequently in various diagnostic procedures.
Authors and Affiliations
Dr. Mujahid Mohammed
Keywords
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