Study of Histopathological Spectrum of Renal Neoplasms in Nephrectomy Specimens from a Tertiary Hospital in North Karnataka, India
Journal Title: National Journal of Laboratory Medicine - Year 2018, Vol 7, Issue 3
Abstract
Introduction: Renal Cell Carcinoma (RCC) ranks 13th most common malignancy worldwide. Majority of the renal tumours are RCCs with very few cases presenting with the classical triad of flank pain, haematuria and mass per abdomen. Partial or total nephrectomy remains the treatment of choice in these patients. A systematic gross and microscopic examination of nephrectomy specimens is pivotal in determining the tumour type and its prognostic indicators namely tumour grade and stage for arriving at a complete treatment protocol. Aim: This study from a tertiary care hospital was undertaken to determine the most common clinical presentation, with age and sex distribution of renal tumours and to analyse the histomorphological spectrum of renal tumours from resected nephrectomy specimens. Materials and Methods: A total of 32 nephrectomy cases were studied during this period. Histopathological parameters were assessed as per CAP guidelines 2017. Tumours were sub typed according to WHO classification 2016 and Fuhrman’s nuclear grade and TNM tumour stage were assessed. The statistical analysis was done using the Statistical Package for the Social Sciences version 20.0 (SPSS Inc. Chicago, IL, USA). Results: The present study included 32 cases. The mean age of presentation was 43.43 years with flank pain being the most common clinical presentation in 17 (53.1%) cases. Histopathological evaluation revealed malignant neoplasm in 28 (87.5%) cases and benign neoplasm in 4 (12.5%) cases. Among malignant tumours, clear cell RCC was the most frequent tumour in our study observed in 15 (46.9%) cases, followed by papillary RCC in 5 (15.6%) cases, 3 (9.4%) cases of Wilms tumour, 2 (6.3%) cases of squamous cell carcinoma, and 1 (3.1%)case each of synovial sarcoma, chromophobe rcc and rhabdoid tumour. Conclusion: Malignant renal tumours far out numbered the benign tumours in our study with RCC being the most common malignant tumour in adults. Wilms tumour was the most common malignancy in paediatric age group. Majority of the tumours showed Fuhrman’s nuclear Grade 2 seen in 50% of the cases.
Authors and Affiliations
Basavaraj Yamakanamardi, Hephzibah Rani, Udupi Shastry Dinesh
Keywords
Related Articles
- EP ID EP534961
- DOI 10.7860/NJLM/2018/36962:2297
- Views 148
- Downloads 0
Immunophenotypic and Morphological Profile of Basal like and non Basal like Invasive Breast Carcinoma
Introduction: Breast carcinomas are heterogeneous disease with different prognosis and therapy responses despite similarities in histological types, grade and stage. Recently, gene expression profiling, a method using cD...
Synchronous Gastrointestinal Stromal Tumor and Adenocarcinoma in the Stomach
Gastrointestinal Stromal Tumor (GIST) is the most common mesenchymal tumor in GIT. However, the synchronous coexistence of GIST with other gastrointestinal malignancy is not so common. Herein, we report an unusual case o...
A Rare Causative Agent of Neonatal Sepsi̇s: Pseudomonas Mendocina
ABSTRACT Pseudomonas mendocina was discovered in 1970 in Mendoza, Argentina, is a Gram negative, non-fermentative bacillus and commonly found in soil and water. A little is known about its pathogenicity or virulence fact...
To Determine the Prevalence and Clinical Significance of Detection of Micro-organisms in Pap Smear with Seasonal Variation
Introduction: The most common problem in reproductive age group women is vaginitis. In the vaginal flora an extensive and diverse spectrum of pathogenic agents may be observed. The important infectious agents in vaginal...
Fine Needle Aspiration Study of Cutaneous Metastatic Deposits in a Tertiary Care Centre in South India
Introduction: Cutaneous metastases are seen with a wide variety of internal malignancies. Cutaneous metastases are clinically important because they may represent the terminal stage of carcinoma, sign of relapse followin...