Study of Histopathological Spectrum of Renal Neoplasms in Nephrectomy Specimens from a Tertiary Hospital in North Karnataka, India
Journal Title: National Journal of Laboratory Medicine - Year 2018, Vol 7, Issue 3
Abstract
Introduction: Renal Cell Carcinoma (RCC) ranks 13th most common malignancy worldwide. Majority of the renal tumours are RCCs with very few cases presenting with the classical triad of flank pain, haematuria and mass per abdomen. Partial or total nephrectomy remains the treatment of choice in these patients. A systematic gross and microscopic examination of nephrectomy specimens is pivotal in determining the tumour type and its prognostic indicators namely tumour grade and stage for arriving at a complete treatment protocol. Aim: This study from a tertiary care hospital was undertaken to determine the most common clinical presentation, with age and sex distribution of renal tumours and to analyse the histomorphological spectrum of renal tumours from resected nephrectomy specimens. Materials and Methods: A total of 32 nephrectomy cases were studied during this period. Histopathological parameters were assessed as per CAP guidelines 2017. Tumours were sub typed according to WHO classification 2016 and Fuhrman’s nuclear grade and TNM tumour stage were assessed. The statistical analysis was done using the Statistical Package for the Social Sciences version 20.0 (SPSS Inc. Chicago, IL, USA). Results: The present study included 32 cases. The mean age of presentation was 43.43 years with flank pain being the most common clinical presentation in 17 (53.1%) cases. Histopathological evaluation revealed malignant neoplasm in 28 (87.5%) cases and benign neoplasm in 4 (12.5%) cases. Among malignant tumours, clear cell RCC was the most frequent tumour in our study observed in 15 (46.9%) cases, followed by papillary RCC in 5 (15.6%) cases, 3 (9.4%) cases of Wilms tumour, 2 (6.3%) cases of squamous cell carcinoma, and 1 (3.1%)case each of synovial sarcoma, chromophobe rcc and rhabdoid tumour. Conclusion: Malignant renal tumours far out numbered the benign tumours in our study with RCC being the most common malignant tumour in adults. Wilms tumour was the most common malignancy in paediatric age group. Majority of the tumours showed Fuhrman’s nuclear Grade 2 seen in 50% of the cases.
Authors and Affiliations
Basavaraj Yamakanamardi, Hephzibah Rani, Udupi Shastry Dinesh
Keywords
Related Articles
- EP ID EP534961
- DOI 10.7860/NJLM/2018/36962:2297
- Views 150
- Downloads 0
Metaplastic Carcinoma Breast with Chondroid Differentiation: A Rare Case Report and Review of Literature
Metaplastic carcinoma of the breast is a rare tumour. Though metaplastic carcinoma is by itself a rare entity, however metaplastic carcinoma with chondroid differentiation makes it even rarer. These tumours are ER, PR, H...
Discriminant Functions in the Diagnosis of Vitamin B12 Deficiency Anemia, the Value of RDW-SD: An Analytical Study
Introduction: Mean Corpuscular Volume (MCV) has been proposed as the most sensitive hematological indicator of vitamin B12 / folate deficiencies and it tends to increase in these patients even before hemoglobin levels de...
Histopathological Spectrum of Premalignant and Malignant Lesions of Uterine Cervix
ABSTRACt Introduction: Cervical cancer is the most common cancer in Indian women and arises after many years from morphologically defined precancerous lesions. There is a considerable variation in diagnostic criteria for...
Isolated Langerhans Cell Histiocytosis of Thyroid-Masquerading as a Thyroid Neoplasm - A Rare Case Report
ABSTRACT Langerhans Cell Histiocytosis (LCH) is a rare neoplastic disease of unknown etiology characterized by oligoclonal proliferation of langerhans cells with a varying incidence rate of 4-5.4 per 1 million individual...
Diagnostic Efficacy of Fine Needle Aspiration Cytology in Cystic Lesions of Head and Neck Region - A single Experience at Tertiary Health Care Centre
Introduction: The cystic lesions of head and neck region are common presentation in the Outpatient Department and encompass a wide spectrum of differential diagnosis, ranging from inflammation to malignancy. Though, Fine...