Study of influence of surface-active substances сoncentration on diltiazem releasing from rectal suppositories
Journal Title: Фармацевтичний журнал - Year 2015, Vol 1, Issue 1
Abstract
Diltiazem is one of the most widely used calcium antagonist in clinical practice. The results of its action are the lowering of myocardium oxygen need, improvement of the coronary blood flow and reducing of arterial pressure. Side effects of its oral and injection administration can be smoothed over by the transmucosal administration of diltiazem, in particular rectal with using of suitable dosage forms. The aim of this work is study of influence of surface-active substances (distilled monoglycerides) concentration on diltiazem releasing from rectal suppositories on factory fatty base which was carried out by the Kruvchinsky’s equilibrium dialysis method. Concentration of diltiazem in dialysates was determined by the spectrophotometric method. As a result of carried out biopharmaceutical investigation it was determined that concentration of the distilled monoglycerides in amount of 2% from suppository mass provided with optimal level of diltiazem releasing from a rectal dosage form.
Authors and Affiliations
K. R. Kuchina, V. V. Gladyshev, I. L. Kechin, I. A. Biruk
Keywords
Related Articles
- EP ID EP574820
- DOI -
- Views 67
- Downloads 0
Development of methods for identification and assay of Himopiron
For medicines implementation to medical practice, their quality-control techniques developed are required to produce analytical and regulative documentation in accordance with existing current demands. The aim of the st...
Use of modeling in the study of economic burden of influenza in the elderly population in Central and Eastern European countries
The economic burden of the incidence of influenza and ARI requires careful study, since annually about 15% of the world's population suffers from these diseases. In addition, the flu can cause complications that are dang...
Medical and pharmaceutical law: application of analgesic drugs as part of the formulary system of Ukraine
The article presents the results of the research of areas of medical and pharmaceutical use of analgesic drugs within the formulary system of Ukraine on the principles of medical and pharmaceutical law.The aim of the res...
Scientific methodology and practical use of managed entry agreements for innovative medicines in system of health technology assessment in Ukraine
In the Health Technology Assessment (HTA) system, it is advisable to use a mini-HTA to save budget funds at the hospital level, taking into account real world data on drug consumption for a rational use of resources at t...
Determination of the qualitative and quantitative content of hydroxycinnamic acids in Gentiana Cruciata L. herb
Gentiana cruciata L. is a herbaceous perennial flowering plant in the Gentianaceae family. This plant is widespread in the territory of Ukraine, namely the southern forest areas, forest-steppe and Crimea. Gentiana crucia...