Study of influence of surface-active substances сoncentration on diltiazem releasing from rectal suppositories
Journal Title: Фармацевтичний журнал - Year 2015, Vol 1, Issue 1
Abstract
Diltiazem is one of the most widely used calcium antagonist in clinical practice. The results of its action are the lowering of myocardium oxygen need, improvement of the coronary blood flow and reducing of arterial pressure. Side effects of its oral and injection administration can be smoothed over by the transmucosal administration of diltiazem, in particular rectal with using of suitable dosage forms. The aim of this work is study of influence of surface-active substances (distilled monoglycerides) concentration on diltiazem releasing from rectal suppositories on factory fatty base which was carried out by the Kruvchinsky’s equilibrium dialysis method. Concentration of diltiazem in dialysates was determined by the spectrophotometric method. As a result of carried out biopharmaceutical investigation it was determined that concentration of the distilled monoglycerides in amount of 2% from suppository mass provided with optimal level of diltiazem releasing from a rectal dosage form.
Authors and Affiliations
K. R. Kuchina, V. V. Gladyshev, I. L. Kechin, I. A. Biruk
Keywords
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