Study of Lipid Profile Changes in Cirrhosis of Liver
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 3
Abstract
Introduction: Cirrhosis is defined anatomically as a diffuse process with fibrosis and nodule formation. It is the result of the fibrogenesis that occurs with chronic liver injury. For reduced liver biosynthesis capacity, low level of triglyceride and cholesterol is usually observed in the chronic liver disease. Due to the high prevalence of chronic liver disease in our country we have conducted this study to determine lipid profile in a patient with cirrhosis and to assess its relationship to the severity of cirrhosis. Purpose of Study: The purpose of this study was to study the serum lipid profile changes in liver cirrhosis patients in comparison to age- and sex-matched apparently healthy control patients and to find the significance of lipid abnormalities in liver cirrhosis patients with the severity of cirrhosis of the liver. Materials and Methods: The present study had been carried out in the Department of Medicine, Medical College and associated Hospital, Jabalpur (Madhya Pradesh) India, from March 2016 to August 2017. This was a case–control observational study. The targeted populations were 75 of cases with liver cirrhosis and age- and sex-matched 75 apparently healthy control patients. Results: There was a significant decrease in serum high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, very low-density lipoprotein (VLDL), and total cholesterol in cases as compared to controls. Of 75 cases, one (1.30%) was belonging to Child-Turcotte-Pugh (CTP) Class A, 34 (45.30%) to Class B, and 40 (53.30%) to Class C. All lipid profile parameters were decreased more in CTP-C compared to CTP-B. Conclusion: We have concluded that there was a significant decrease in serum total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol, and serum triglyceride level in liver cirrhosis patients which belongs to the Child-Pugh Class C.
Authors and Affiliations
Jitendra Kumar Jatav, Rajeev Kumar Shakya, Sandeep Singh
Keywords
Related Articles
- EP ID EP480147
- DOI -
- Views 113
- Downloads 0
Comparing the Analgesic Efficacy of Parecoxib and Rofecoxib for Post-operative Analgesia Following Lower Abdominal Surgery
Background: This study tested the hypothesis that an intravenous parecoxib 40 mg and deep intragluteal rofecoxib 40 mg will be effective for post-operative pain relief after hysterectomy and well tolerated. Materials and...
Knowledge, Attitude and Practice toward Diabetic Retinopathy and Retinal Examination among Diabetic Population in Al-Hasa Region, Saudi Arabia: A Cross-sectional Study
Introduction: Diabetic retinopathy (DR) is a major health concern in diabetic patients. It is considered as a silent developing disease that eventually can lead to blindness. Therefore, it is important for diabetic popul...
A Hospital Based Study on Correlation between Transvaginal Sonography and Histopathological Pattern in the Diagnosis of Adenomyosis
Background: Adenomyosis is a common benign disease of the uterus with an incidence of 5-70% in combined surgical and postmortem specimens. It may be diagnosed using transabdominal ultrasonography, transvaginal ultrasonog...
Clinical Outcome of Borderline Subdural Hematoma with 5-9 mm Thickness and/or Midline Shift 2-5 mm
Introduction: Patients with a subdural hematoma (SDH) and midline shift (MLS) of <10 mm on the computed tomography scans and with a Glasgow coma scale (GCS) score of 15 initially might be treated conservatively under clo...
A Study of Modified Alvarado Score and Rovsing’s Sign in Diagnosis of Acute Appendicitis
Background: Acute appendicitis remains a common abdominal emergency throughout the world. The diagnosis of acute appendicitis continues to be difficult due to the variable presentation of the disease and the lack of reli...