Study of lipid profile, lipid peroxidase, glutathione peroxidase, superoxide dismutase and catalase inDiabetes and non-diabetic foot ulcer patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Oxidative stress (OS) and lipid peroxidation has been associated in the development of diabetic complications including diabetic foot ulcer. In this study, the levels of lipid peroxides (LPO), catalase and lipid profile as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer subjects were assessed and compared with apparently healthy normal subjects to understand the involvement of OS in the subjects. It was found that level of mean TC, TC and LDL had decreased in type 2 DM with foot ulcer, type2 DM without foot ulcer, non-diabetic foot ulcer and healthy control respectively and this difference was statistically significant. Level of mean HDL had significantly lower in type 2 DM with foot ulcer.Mean lipid peroxidase level had significantly higher in type2 DM with foot ulcer and non-diabetic foot ulcer (p<0.0001). Mean SOD level had significantly higher in type2 DM with foot ulcer and non-diabetic foot ulcer (p<0.0001). Mean Catalase level had significantly higher in type2 DM with foot ulcer and non-diabetic foot ulcer (p=0.0135). Increased lipid profile subsequent to diabetic conditions of foot ulcer induces an over-expression of lipid peroxidase, SOD and Catalase activity suggesting a compensatory mechanism by the body to prevent further tissue damage in the subjects.
Authors and Affiliations
Dr. Prasanta Kumar Bhattacharyya, Priyanka Biswas, Dr. Debarshi Jana, Dr. Jayanta Mukherjee, Dr. Madhusanta De
Keywords
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- EP ID EP467721
- DOI 10.9790/0853-1802134954.
- Views 73
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