Study of Melanin Subacute Toxicity According to the Indices of Biochemical and Morphological Liver Changes in Rats
Journal Title: Український журнал сучасних проблем токсикології - Year 2017, Vol 80, Issue 4
Abstract
Sub-acute toxicity of a natural pigment melanin, produced by Antarctic yeast-like fungi Pseudonadsoniella brunnea was studied in rats. Morphological and biochemical changes in liver of rats following 14-day intragastric treatment with melanin in doses 50,100, or 200 mg/kg bw were evaluated. It was shown that melanin injections did not cause significant pathological changes in the rats liver. This presumes melanin to be safety used for long-term treatments.
Authors and Affiliations
O. K. Voronina, D. V. Holyshkin, S. M. Berehovyi, T. V. Berehova, L. І. Ostapchenko
Keywords
Related Articles
- EP ID EP309218
- DOI -
- Views 113
- Downloads 0
Changes in integral indicators of the functional state of experimental animals with the long-term introduction of cadmium chloride and nanoparticles of sulfide cadmium of different sizes
The purpose of the study was a comparative assessment of the integral indicators of the functional state of experimental animals under conditions of prolonged exposure to cadmium chloride and nanoparticles (NP) of cadmiu...
Toxicants of anticholinesterase action: mechanism of action, clinical signs and existing questions of supply by antidotal therapy
The article is devoted to the current problem — the deterioration of the current state of chemical safety in Ukraine, the spread of the use of organophosphorus compounds in agriculture, life, pharmaceutical and chemical...
Використання мікроядерного тесту для скринінгу та моніторингу мутагенів. Історичні контролі
Вступ. Аналіз мутагенної активності — обов’язковий елемент токсикологічної оцінки пестицидів при їх регламентуванні в середовищі життєдіяльності людини. Для оцінки результатів досліджень поточні дані експериментів порівн...
Regulation of diisodecyl phthalate plasticizer in the air of working zone
Objective. Based on the analysis and compilation of the literature data and own studies on toxicological characteristics of diisodecyl phthalate plasticizer, substantiation of its tentative safe exposure level in the air...
Study of the effect of four generic lambda-cyhalothrin pesticides on the reproductive function of male wistar han rats
Introduction. Objective is to identify hazard and asses reproductive toxicity risk of four generic lambda-cyhalothrin pesticides of different purity on male Wistar Han rats. Methods. Lambda-cyhalothrin (LC1 — 97 %, LC2 —...