Study of oxidative stress in women with preeclampsia
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Root cause of preeclampsia is placental ischemia due to impaired trophoblastic invasion in uterine spiral arterioles. Ischemic placenta liberates various inflammatory mediators. Inflammation is associated with development of free radicals leading to vascular endothelial damage. Therefore estimation of oxidative stress can give insight to pathogenesis of disease. Objectives: To compare oxidative stress among women with preeclampsia & normal pregnancy. Materials and Method: Thirty pre-eclamptic women and thirty women with normal pregnancy were included in study as cases and controls respectively. Serum levels of MDA, vitamin C & uric acid were estimated. Data was compared using unpaired student’s t-test done by SPSS 17.0 software. Results: Cases were having significantly higher serum MDA levels than controls. There were significantly lower serum levels of vitamin C & uric acid in cases than controls (p<0.05). Conclusions: Significantly increased level of MDA & decreased level of Vitamin C & uric acid in pre-eclamptic mothers suggests that increased oxidative stress and preeclampsia are associated with each other. Elevated oxidative stress is independent risk factor for vascular diseases so it can be used as a biomarker to identify women at risk.
Authors and Affiliations
Amit D. Sonagra, Asmabi Makandar, Zahoorunissa Deba, Shylaja TV, K. Dattatreya
Keywords
Related Articles
- EP ID EP297181
- DOI 10.18231/2394-6377.2017.0057
- Views 57
- Downloads 0
Study of serum zinc and copper level in children with malarial infection in Civil Hospital, Ahmedabad
Introduction: Malaria is a major protozoal disease in developing countries responsible for 2-3 million deaths per year. Zinc (Zn) and copper (Cu) are involved in numerous aspects of cellular metabolism. They are required...
Correlation of lipid profile with tobacco use in cataract patients
Introduction: Human beings are blessed with five special senses and vision is the most precious. Cataract is the major cause of a visual impairment. Tobacco use is a modifiable risk factor for cataract. Dyslipidemia is a...
Evaluation of Adenosine deaminase, Serum C-reactive protein and alkaline phosphatase activity in Rheumatoid Arthritis patients in Shivamogga district, South India
Introduction & Objectives: Rheumatoid arthritis (RA) is a prototypical inflammatory joint disease. The degree of inflammation is reflected in the extent of joint damage, which further has influence on the quality of life...
High sensitivity–c reactive protein as an additional marker for increased risk of cardiovascular disease in patients of polycystic ovary syndrome
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age group with a worldwide prevalence of about 4 to12%1,2 . PCOS is seen in up to 25% of the Caucasians a...
Current Understanding in the Measurement of Low Density Lipoprotein Cholesterol: A Comparison of Direct Measurement by Homogenous Assays versus Calculations
Background: To compare the results obtained by direct homogenous assay for LDL-C to those obtained by Friedwalds and Anandrajas formulas with the assumption that the results obtained by direct assay are most accurate. Th...