STUDY OF PERIPHERAL SMEARS IN NEONATES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 29
Abstract
BACKGROUND The haematological parameters in a newborn are distinctly different from the normal adult values. NRBCs are immature RBCs normally seen in the peripheral blood of neonates up to 5 th day of life. At birth, 3 to 10 NRBCs per 100 WBCs are present. Premature birth and foetal hypoxia can cause the number to increase. NRBC count in umbilical venous blood of neonates has been reported as a possible marker of perinatal asphyxia. Leukocytosis refers to an increase in the total number of WBCs due to any cause. Thrombocytopenia can be a marker of an underlying disease as well as an obvious risk factor for haemorrhage. We wanted to study the variations in RBC, WBC, and platelets in peripheral smear of neonates and correlate them with the clinical findings. METHODS 300 cases were undertaken in this prospective study held between January 2012 and September 2013. Peripheral smear slides of all term neonates born in A. J. Hospital, Mangalore during this time period were taken and stained with Leishman’s stain. The data obtained was extensively studied and statistical analysis was done by Pearson’s Chi square test and Fischer’s Exact test. RESULTS The mean age of the study group was 1.29 days with female predominance, constituting 67%. 94.3% cases had normal RBC morphology. Anaemia amounted to 5.7% (17) cases. 91% cases had normal WBC count and 9% (27) cases had leukocytosis. HSS score was 4 for 8% (24) cases of which 7% (21) cases had leukocytosis and 1% (3) cases had normal WBC count. HSS score was 5 for 10% (3) cases, of which 7% (2) cases had leukocytosis and 3% (1) cases had normal WBC count. Normal platelet count was seen in 89.7% (269) cases with thrombocytopenia in 10.3% (31) cases. CONCLUSIONS Peripheral blood film remains a very useful diagnostic tool in haematological assessment, and assessing the HSS score is important as it is a useful test to distinguish the infected from the non-infected newborn which will help the clinicians to reach a probable diagnosis, decreasing the death toll and institute a rational approach towards patient medication.
Authors and Affiliations
Blessy Mary Thomas, Reni Gee Varghese
Keywords
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- EP ID EP670348
- DOI 10.18410/jebmh/2019/401
- Views 100
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