Study of prognostic significance of serum levels of creatine kinase in Organophosphorus poisoning cases
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 7
Abstract
Introduction: Organophosphorus poisoning is wildly used insecticide in developing country like India because of its easy availability. Organophosphorus compound poisoning being very common poisoning causing high mortality rate. Various clinical markers can be relevant in evaluation of the patients but the role of serum enzymes such as creatine kinase have been studied with many contradictory reports in the literature, which led us to plan this study to understand the prognostic significance of serum creatinine kinase in the patients of OP poisoning and their correlation with the outcomes. Material and Methods: we conducted a prospective study in 100 patients of OP poisoning who were followed up from admission to discharge or death. Serum creatine kinase analyzed to find their relationship with outcome parameters such as total dose of atropine needed until final outcome, requirement of mechanical ventilation, total hospital stay. Results: The patients had a mean age of 32.4 ± 13.5 years with male to female gender ratio of approximately 5. Study population had mean hospital stay duration of 5.5 ± 3.49 days. The overall mortality was 21%. Mortality of patients with raised serum creatine kinase was significantly higher (0.039) than the patient with normal levels Patients who had raised creatine kinase levels had significantly higher mortality, hospital stay, total atropine dose and necessity for mechanical ventilation. Conclusion: Serum creatine kinase is raised in almost one third of the patients of organophosphorus poisoning and its baseline level could help in predicting the outcomes in terms of atropine dose required, hospital stay, mortality. We recommend Creatine kinase levels as alternate prognostic biomarkers in Organophosphorus poisoning.
Authors and Affiliations
Dr. Abhijeet Gaikwad
Keywords
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