Study of Response to Treatment with AntithymocyticGlobulin (Atg) +Cyclosporine (Csa) In Aplastic Anemia
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: Aplastic anemia is disorder of Bone marrow failure causing peripheral cytopenias and causing huge morbidity and mortality. It is treated with Cyclosporine (CSA), Antithymocytic globulin (ATG) and Bone marrow transplantation. Our aim of the study is study the response to Antithymocytic globulin plus Cyclosporine in Aplastic Anemia. All patients who opted for treatment with ATG+CSA were recruited. This study was conducted over a period of 5 years, Total 60 patients were recruited, but finally 55patients were included with mean age of 29years,and male to female ratio of1.6 to1.and followed up for 3 months. The commonest symptom was bleeding gums 75%, shortness of breath 41.66% and the commonest sign was pallor in66.66%. Out of 60 patients 58 required component support before treatment with ATG+CSA.There 61.8% patients responded, among them, complete response was seen in 22(66%), and partial responsewas seen in11 (33%).3 patients died, 1 patient had renal failure, and 35 (63.63%) had serum sickness. Keywords:Aplastic anemia,Antithymocyticglobulin,Cyclosporine,Bone marrow transplantation,Neutropenia,Hemoglobin
Authors and Affiliations
Mallikarjuna Shetty, Nageswer Rao Modugu, Narendra Ankonda Moti Venkata Raj
Keywords
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